Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B)
1_MASEV 6_ VCGLI 11_ FRLLL 16_ PICLA 21_ VACAF 26_ RYNGL 31_ SFVYL 36_ IYLLL 41_ IPLFS 46_ EPTKT 51_ TMQGH 56_ TGRLL 61_ KSLCF 66_ ISLSF 71_ LLLHI 76_ IFHIT 81_ LVSLE 86_ AQHRI 91_ APGYN 96_ CSTWE 101_ KTFRQ 106_ IGFES 111_ LKGAD 116_ AGNGI 121_ RVFVP 126_ DIGMF 131_ IASLT 136_ IWLLC 141_ RNIVQ 146_ KPVTD 151_ EAAQS 156_ NPEFE 161_ NEELA 166_ EGEKI 171_ DSEEA 176_ LIYEE 181_ DFNGG 186_ DGVEG 191_ ELEES 196_ TKLKM 201_ FRRLA 206_ SVASK 211_ LKEFI 216_ GNMIT 221_ TAGKV 226_ VVTIL 231_ LGSSG 236_ MMLPS 241_ LTSSV 246_ YFFVF 251_ LGLCT 256_ WWSWC 261_ RTFDP 266_ LLFSC 271_ LCVLL 276_ AIFTA 281_ GHLIG 286_ LYLYQ 291_ FQFFQ 296_ EAVPP 301_ NDYYA 306_ RLFGI 311_ KSVIQ 316_ TDCSS 321_ TWKII 326_ VNPDL 331_ SWYHH 336_ ANPIL 341_ LLVMY 346_ YTLAT 351_ LIRIW 356_ LQEPL 361_ VQDEG 366_ TKEED 371_ KALAC 376_ SPIQI 381_ TAGRR 386_ RSLWY 391_ ATHYP 396_ TDERK 401_ LLSMT 406_ QDDYK 411_ PSDGL 416_ LVTVN 421_ GNPVD 426_ YHTIH 431_ PSLPM 436_ ENGPG 441_ KADLY 446_ STPQY 451_ RWEPS 456_ DESSE 461_ KREEE 466_ EEEKE 471_ EFEEE 476_ RSREE 481_ KRSIK 486_ VHAMV 491_ SVFQF 496_ IMKQS 501_ YICAL 506_ IAMMA 511_ WSITY 516_ HSWLT 521_ FVLLI 526_ WSCTL 531_ WMIRN 536_ RRKYA 541_ MISSP 546_ FMVVY 551_ GNLLL 556_ ILQYI 561_ WSFEL 566_ PEIKK 571_ VPGFL 576_ EKKEP 581_ GELAS 586_ KILFT 591_ ITFWL 596_ LLRQH 601_ LTEQK 606_ ALQEK 611_ EALLS 616_ EVKIG 621_ SQENE 626_ EKDEE 631_ LQDIQ 636_ VEGEP 641_ KEEEE 646_ EEAKE 651_ EKQER 656_ KKVEQ 661_ EEAEE 666_ EDEQD 671_ IMKVL 676_ GNLVV 681_ AMFIK 686_ YWIYV 691_ CGGMF 696_ FFVSF 701_ EGKIV 706_ MYKII 711_ YMVLF 716_ LFCVA 721_ LYQVH 726_ YEWWR 731_ KILKY 736_ FWMSV 741_ VIYTM 746_ LVLIF 751_ IYTYQ 756_ FENFP 761_ GLWQN 766_ MTGLK 771_ KEKLE 776_ DLGLK 781_ QFTVA 786_ ELFTR 791_ IFIPT 796_ SFLLV 801_ CILHL 806_ HYFHD 811_ RFLEL 816_ TDLKS 821_ IPSKE 826_ DNTIY 831_ RLAHP 836_ EGSLP 841_ DLTMM 846_ HLTAS 851_ LEKPE 856_ VRKLA 861_ EPGEE 866_ KLEGY 871_ SEKAQ 876_ KGDLG 881_ KDSEE 886_ SEEDG 891_ EEEEE 896_ SEEEE 901_ ETSDL 906_ RNKWH 911_ LVIDR 916_ LTVLF 921_ LKFLE 926_ YFHKL 931_ QVFMW 936_ WILEL 941_ HIIKI 946_ VSSYI 951_ IWVSV 956_ KEVSL 961_ FNYVF 966_ LISWA 971_ FALPY 976_ AKLRR 981_ LASSV 986_ CTVWT 991_ CVIIV 996_ CKMLY 1001_ QLQTI 1006_ KPENF 1011_ SVNCS 1016_ LPNEN 1021_ QTNIP 1026_ FNELN 1031_ KSLLY 1036_ SAPID 1041_ PTEWV 1046_ GLRKS 1051_ SPLLV 1056_ YLRNN 1061_ LLMLA 1066_ ILAFE 1071_ VTIYR 1076_ HQEYY 1081_ RGRNN 1086_ LTAPV 1091_ SRTIF 1096_ HDITR 1101_ LHLDD 1106_ GLINC 1111_ AKYFI 1116_ NYFFY 1121_ KFGLE 1126_ TCFLM 1131_ SVNVI 1136_ GQRMD 1141_ FYAMI 1146_ HACWL 1151_ IAVLY 1156_ RRRRK 1161_ AIAEI 1166_ WPKYC 1171_ CFLAC 1176_ IITFQ 1181_ YFICI 1186_ GIPPA 1191_ PCRDY 1196_ PWRFK 1201_ GASFN 1206_ DNIIK 1211_ WLYFP 1216_ DFIVR 1221_ PNPVF 1226_ LVYDF 1231_ MLLLC 1236_ ASLQR 1241_ QIFED 1246_ ENKAA 1251_ VRIMA 1256_ GDNVE 1261_ ICMNL 1266_ DAASF 1271_ SQHNP 1276_ VPDFI 1281_ HCRSY 1286_ LDMSK 1291_ VIIFS 1296_ YLFWF 1301_ VLTII 1306_ FITGT 1311_ TRISI 1316_ FCMGY 1321_ LVACF 1326_ YFLLF 1331_ GGDLL 1336_ LKPIK 1341_ SILRY 1346_ WDWLI 1351_ AYNVF 1356_ VITMK 1361_ NILSI 1366_ GACGY 1371_ IGTLV 1376_ HNSCW 1381_ LIQAF 1386_ SLACT 1391_ VKGYQ 1396_ MPAAN 1401_ SPCTL 1406_ PSGEA 1411_ GIIWD 1416_ SICFA 1421_ FLLLQ 1426_ RRVFM 1431_ SYYFL 1436_ HVVAD 1441_ IKASQ 1446_ ILASR 1451_ GAELF 1456_ QATIV 1461_ KAVKA 1466_ RIEEE 1471_ KKSMD 1476_ QLKRQ 1481_ MDRIK 1486_ ARQQK 1491_ YKKGK 1496_ ERMLS 1501_ LTQEP 1506_ GEGQD 1511_ MQKLS 1516_ EEDDE 1521_ READK 1526_ QKAKG 1531_ KKKQW 1536_ WRPWV 1541_ DHASM 1546_ VRSGD 1551_ YYLFE 1556_ TDSEE 1561_ EEEEE 1566_ LKKED 1571_ EEPPR 1576_ RSAFQ 1581_ FVYQA 1586_ WITDP 1591_ KTALR 1596_ QRHKE 1601_ KKRSA 1606_ REERK 1611_ RRRKG 1616_ SKEGP 1621_ VEWED 1626_ REDEP 1631_ IKKKS 1636_ DGPDN 1641_ IIKRI 1646_ FNILK 1651_ FTWVL 1656_ FLATV 1661_ DSFTT 1666_ WLNSI 1671_ SREHI 1676_ DISTV 1681_ LRIER 1686_ CMLTR 1691_ EIKKG 1696_ NVPTR 1701_ ESIHM 1706_ YYQNH 1711_ IMNLS 1716_ RESGL 1721_ DTIDE 1726_ HPGAA 1731_ SGAQT 1736_ AHRMD 1741_ SLDSH 1746_ DSISS 1751_ EPTQC 1756_ TMLYS 1761_ RQGTT 1766_ ETIEE 1771_ VEAEQ 1776_ EEEAG 1781_ STAPE 1786_ PREAK 1791_ EYEAT 1796_ GYDVG 1801_ AMGAE 1806_ EASLT 1811_ PEEEL 1816_ TQFST 1821_ LDGDV 1826_ EAPPS 1831_ YSKAV 1836_ SFEHL 1841_ SFGSQ 1846_ DDSAG 1851_ KNRMA 1856_ VSPDD 1861_ SRTDK 1866_ LGSSI 1871_ LPPLT 1876_ HELTA 1881_ SELLL 1886_ KKMFH 1891_ DDELE 1896_ ESEKF 1901_ YVGQP 1906_ RFLLL 1911_ FYAMY 1916_ NTLVA 1921_ RSEMV 1926_ CYFVI 1931_ ILNHM 1936_ VSASM 1941_ ITLLL 1946_ PILIF 1951_ LWAML 1956_ SVPRP 1961_ SRRFW 1966_ MMAIV 1971_ YTEVA 1976_ IVVKY 1981_ FFQFG 1986_ FFPWN 1991_ KNVEV 1996_ NKDKP 2001_ YHPPN 2006_ IIGVE 2011_ KKEGY 2016_ VLYDL 2021_ IQLLA 2026_ LFFHR 2031_ SILKC 2036_ HGLWD 2041_ EDDMT 2046_ ESGMA 2051_ REESD 2056_ DELSL 2061_ GHGRR 2066_ DSSDS 2071_ LKSIN 2076_ LAASV 2081_ ESVHV 2086_ TFPEQ 2091_ QTAVR 2096_ RKRSG 2101_ SSSEP 2106_ SQRSS 2111_ FSSNR 2116_ SQRGS 2121_ TSTRN 2126_ SSQKG 2131_ SSVLS 2136_ IKQKG 2141_ KRELY 2146_ MEKLQ 2151_ EHLIK 2156_ AKAFT 2161_ IKKTL 2166_ EIYVP 2171_ IKQFF 2176_ YNLIH 2181_ PEYSA 2186_ VTDVY 2191_ VLMFL 2196_ ADTVD 2201_ FIIIV 2206_ FGFWA 2211_ FGKHS 2216_ AAADI 2221_ TSSLS 2226_ EDQVP 2231_ GPFLV 2236_ MVLIQ 2241_ FGTMV 2246_ VDRAL 2251_ YLRKT 2256_ VLGKV 2261_ IFQVI 2266_ LVFGI 2271_ HFWMF 2276_ FILPG 2281_ VTERK 2286_ FSQNL 2291_ VAQLW 2296_ YFVKC 2301_ VYFGL 2306_ SAYQI 2311_ RCGYP 2316_ TRVLG 2321_ NFLTK 2326_ SYNYV 2331_ NLFLF 2336_ QGFRL 2341_ VPFLT 2346_ ELRAV 2351_ MDWVW 2356_ TDTTL 2361_ SLSSW 2366_ ICVED 2371_ IYAHI 2376_ FILKC 2381_ WRESE 2386_ KRYPQ 2391_ PRGQK 2396_ KKKVV 2401_ KYGMG 2406_ GMIIV 2411_ LLICI 2416_ VWFPL 2421_ LFMSL 2426_ IKSVA 2431_ GVINQ 2436_ PLDVS 2441_ VTITL 2446_ GGYQP 2451_ IFTMS 2456_ AQQSQ 2461_ LKVMD 2466_ QQSFN 2471_ KFIQA 2476_ FSRDT 2481_ GAMQF 2486_ LENYE 2491_ KEDIT 2496_ VAELE 2501_ GNSNS 2506_ LWTIS 2511_ PPSKQ 2516_ KMIHE 2521_ LLDPN 2526_ SSFSV 2531_ VFSWS 2536_ IQRNL 2541_ SLGAK 2546_ SEIAT 2551_ DKLSF 2556_ PLKNI 2561_ TRKNI 2566_ AKMIA 2571_ GNSTE 2576_ SSKTP 2581_ VTIEK 2586_ IYPYY 2591_ VKAPS 2596_ DSNSK 2601_ PIKQL 2606_ LSENN 2611_ FMDIT 2616_ IILSR 2621_ DNTTK 2626_ YNSEW 2631_ WVLNL 2636_ TGNRI 2641_ YNPNS 2646_ QALEL 2651_ VVFND 2656_ KVSPP 2661_ SLGFL 2666_ AGYGI 2671_ MGLYA 2676_ SVVLV 2681_ IGKFV 2686_ REFFS 2691_ GISHS 2696_ IMFEE 2701_ LPNVD 2706_ RILKL 2711_ CTDIF 2716_ LVRET 2721_ GELEL 2726_ EEDLY 2731_ AKLIF 2736_ LYRSP 2741_ ETMIK 2746_WTREK
1: Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity)