Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6)
1_MNMSV 6_ LTLQE 11_ YEFEK 16_ QFNEN 21_ EAIQW 26_ MQENW 31_ KKSFL 36_ FSALY 41_ AAFIF 46_ GGRHL 51_ MNKRA 56_ KFELR 61_ KPLVL 66_ WSLTL 71_ AVFSI 76_ FGALR 81_ TGAYM 86_ VYILM 91_ TKGLK 96_ QSVCD 101_ QGFYN 106_ GPVSK 111_ FWAYA 116_ FVLSK 121_ APELG 126_ DTIFI 131_ ILRKQ 136_ KLIFL 141_ HWYHH 146_ ITVLL 151_ YSWYS 156_ YKDMV 161_ AGGGW 166_ FMTMN 171_ YGVHA 176_ VMYSY 181_ YALRA 186_ AGFRV 191_ SRKFA 196_ MFITL 201_ SQITQ 206_ MLMGC 211_ VVNYL 216_ VFCWM 221_ QHDQC 226_ HSHFQ 231_ NIFWS 236_ SLMYL 241_ SYLVL 246_ FCHFF 251_ FEAYI 256_GKMRK
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators