Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2)
1_MWIPV 6_ VGLPR 11_ RLRLS 16_ ALAGA 21_ GRFCI 26_ LGSEA 31_ ATRKH 36_ LPARN 41_ HCGLS 46_ DSSPQ 51_ LWPEP 56_ DFRNP 61_ PRKAS 66_ KASLD 71_ FKRYV 76_ TDRRL 81_ AETLA 86_ QIYLG 91_ KPSRP 96_ PHLLL 101_ ECNPG 106_ PGILT 111_ QALLE 116_ AGAKV 121_ VALES 126_ DKTFI 131_ PHLES 136_ LGKNL 141_ DGKLR 146_ VIHCD 151_ FFKLD 156_ PRSGG 161_ VIKPP 166_ AMSSR 171_ GLFKN 176_ LGIEA 181_ VPWTA 186_ DIPLK 191_ VVGMF 196_ PSRGE 201_ KRALW 206_ KLAYD 211_ LYSCT 216_ SIYKF 221_ GRIEV 226_ NMFIG 231_ EKEFQ 236_ KLMAD 241_ PGNPD 246_ LYHVL 251_ SVIWQ 256_ LACEI 261_ KVLHM 266_ EPWSS 271_ FDIYT 276_ RKGPL 281_ ENPKR 286_ RELLD 291_ QLQQK 296_ LYLIQ 301_ MIPRQ 306_ NLFTK 311_ NLTPM 316_ NYNIF 321_ FHLLK 326_ HCFGR 331_ RSATV 336_ IDHLR 341_ SLTPL 346_ DARDI 351_ LMQIG 356_ KQEDE 361_ KVVNM 366_ HPQDF 371_ KTLFE 376_ TIERS 381_ KDCAY 386_ KWLYD 391_ETLED
1: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:12068295, PubMed:15526033, PubMed:20410300, PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033, PubMed:29149603). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151)