Cytosolic iron-sulfur assembly component 2A (MIP18 family protein FAM96A)
1_MQRVS 6_ GLLSW 11_ TLSRV 16_ LWLSG 21_ LSEPG 26_ AARQP 31_ RIMEE 36_ KALEV 41_ YDLIR 46_ TIRDP 51_ EKPNT 56_ LEELE 61_ VVSES 66_ CVEVQ 71_ EINEE 76_ EYLVI 81_ IRFTP 86_ TVPHC 91_ SLATL 96_ IGLCL 101_ RVKLQ 106_ RCLPF 111_ KHKLE 116_ IYISE 121_ GTHST 126_ EEDIN 131_ KQIND 136_ KERVA 141_ AAMEN 146_ PNLRE 151_IVEQC
1: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227)