ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein)
1_MLSGI 6_ EAAAG 11_ EYEDS 16_ ELRCR 21_ VAVEE 26_ LSPGG 31_ QPRRR 36_ QALRT 41_ AELSL 46_ GRNER 51_ RELML 56_ RLQAP 61_ GPAGR 66_ PRCFP 71_ LRAAR 76_ LFTRF 81_ AEAGR 86_ STLRL 91_ PAHDT 96_ PGAGA 101_ VQLLL 106_ SDCPP 111_ DRLRR 116_ FLRTL 121_ RLKLA 126_ AAPGP 131_ GPASA 136_ RAQLL 141_ GPRPR 146_ DFVTI 151_ SPVQP 156_ EERRL 161_ RAATR 166_ VPDTT 171_ LVKRP 176_ VEPQA 181_ GAEPS 186_ TEAPR 191_ WPLPV 196_ KRLSL 201_ PSTKP 206_ QLSEE 211_ QAAVL 216_ RAVLK 221_ GQSIF 226_ FTGSA 231_ GTGKS 236_ YLLKR 241_ ILGSL 246_ PPTGT 251_ VATAS 256_ TGVAA 261_ CHIGG 266_ TTLHA 271_ FAGIG 276_ SGQAP 281_ LAQCV 286_ ALAQR 291_ PGVRQ 296_ GWLNC 301_ QRLVI 306_ DEISM 311_ VEADL 316_ FDKLE 321_ AVARA 326_ VRQQN 331_ KPFGG 336_ IQLII 341_ CGDFL 346_ QLPPV 351_ TKGSQ 356_ PPRFC 361_ FQSKS 366_ WKRCV 371_ PVTLE 376_ LTKVW 381_ RQADQ 386_ TFISL 391_ LQAVR 396_ LGRCS 401_ DEVTR 406_ QLQAT 411_ ASHKV 416_ GRDGI 421_ VATRL 426_ CTHQD 431_ DVALT 436_ NERRL 441_ QELPG 446_ KVHRF 451_ EAMDS 456_ NPELA 461_ STLDA 466_ QCPVS 471_ QLLQL 476_ KLGAQ 481_ VMLVK 486_ NLSVS 491_ RGLVN 496_ GARGV 501_ VVGFE 506_ AEGRG 511_ LPQVR 516_ FLCGV 521_ TEVIH 526_ ADRWT 531_ VQATG 536_ GQLLS 541_ RQQLP 546_ LQLAW 551_ AMSIH 556_ KSQGM 561_ TLDCV 566_ EISLG 571_ RVFAS 576_ GQAYV 581_ ALSRA 586_ RSLQG 591_ LRVLD 596_ FDPMA 601_ VRCDP 606_ RVLHF 611_ YATLR 616_ RGRSL 621_ SLESP 626_ DDDEA 631_ ASDQE 636_NMDPI
1: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity