Ankyrin repeat and SOCS box protein 7 (ASB-7)
1_MLHHH 6_ CRRNP 11_ ELQEE 16_ LQIQA 21_ AVAAG 26_ DVHTV 31_ RKMLE 36_ QGYSP 41_ NGRDA 46_ NGWTL 51_ LHFSA 56_ ARGKE 61_ RCVRV 66_ FLEHG 71_ ADPTV 76_ KDLIG 81_ GFTAL 86_ HYAAM 91_ HGRAR 96_ IARLM 101_ LESEY 106_ RSDII 111_ NAKSN 116_ DGWTP 121_ LHVAA 126_ HYGRD 131_ SFVRL 136_ LLEFK 141_ AEVDP 146_ LSDKG 151_ TTPLQ 156_ LAIIR 161_ ERSSC 166_ VKILL 171_ DHNAN 176_ IDIQN 181_ GFLLR 186_ YAVIK 191_ SNHSY 196_ CRMFL 201_ QRGAD 206_ TNLGR 211_ LEDGQ 216_ TPLHL 221_ SALRD 226_ DVLCA 231_ RMLYN 236_ YGADT 241_ NTRNY 246_ EGQTP 251_ LAVSI 256_ SISGS 261_ SRPCL 266_ DFLQE 271_ VTRQP 276_ RNLQD 281_ LCRIK 286_ IRQCI 291_ GLQNL 296_ KLLDE 301_ LPIAK 306_ VMKDY 311_LKHKF
1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a role in spindle dynamics and genome integrity by targeting the mitotic progression protein PSRC1 for proteasomal degradation in a cell cycle-dependent manner (PubMed:27697924). Also participates in meiosis by mediating the proper attachment between kinetochores and microtubules (By similarity)