XK-related protein 8 (hXkr8) [Cleaved into: XK-related protein 8, processed form]
1_MPWSS 6_ RGALL 11_ RDLVL 16_ GVLGT 21_ AAFLL 26_ DLGTD 31_ LWAAV 36_ QYALG 41_ GRYLW 46_ AALVL 51_ ALLGL 56_ ASVAL 61_ QLFSW 66_ LWLRA 71_ DPAGL 76_ HGSQP 81_ PRRCL 86_ ALLHL 91_ LQLGY 96_ LYRCV 101_ QELRQ 106_ GLLVW 111_ QQEEP 116_ SEFDL 121_ AYADF 126_ LALDI 131_ SMLRL 136_ FETFL 141_ ETAPQ 146_ LTLVL 151_ AIMLQ 156_ SGRAE 161_ YYQWV 166_ GICTS 171_ FLGIS 176_ WALLD 181_ YHRAL 186_ RTCLP 191_ SKPLL 196_ GLGSS 201_ VIYFL 206_ WNLLL 211_ LWPRV 216_ LAVAL 221_ FSALF 226_ PSYVA 231_ LHFLG 236_ LWLVL 241_ LLWVW 246_ LQGTD 251_ FMPDP 256_ SSEWL 261_ YRVTV 266_ ATILY 271_ FSWFN 276_ VAEGR 281_ TRGRA 286_ IIHFA 291_ FLLSD 296_ SILLV 301_ ATWVT 306_ HSSWL 311_ PSGIP 316_ LQLWL 321_ PVGCG 326_ CFFLG 331_ LALRL 336_ VYYHW 341_ LHPSC 346_ CWKPD 351_ PDQVD 356_ GARSL 361_ LSPEG 366_ YQLPQ 371_ NRRMT 376_ HLAQK 381_ FFPKA 386_KDEAA
1: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine (PubMed:23845944). Promotes myoblast differentiation and survival (PubMed:28881496)
2: (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles (PubMed:29338048). Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells (PubMed:29338048)