Fibronectin type III domain-containing protein 4 (Fibronectin type III repeat-containing protein 1)
1_MPSGC 6_ HSSPP 11_ SGLRG 16_ DMASL 21_ VPLSP 26_ YLSPT 31_ VLLLV 36_ SCDLG 41_ FVRAD 46_ RPPSP 51_ VNVTV 56_ THLRA 61_ NSATV 66_ SWDVP 71_ EGNIV 76_ IGYSI 81_ SQQRQ 86_ NGPGQ 91_ RVIRE 96_ VNTTT 101_ RACAL 106_ WGLAE 111_ DSDYT 116_ VQVRS 121_ IGLRG 126_ ESPPG 131_ PRVHF 136_ RTLKG 141_ SDRLP 146_ SNSSS 151_ PGDIT 156_ VEGLD 161_ GERPL 166_ QTGEV 171_ VIIVV 176_ VLLMW 181_ AAVIG 186_ LFCRQ 191_ YDIIK 196_ DNDSN 201_ NNPKE 206_ KGKGP 211_ EQSPQ 216_ GRPVG 221_ TRQKK 226_SPSIN
1: Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation, via interaction with GPR116. Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake. The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling