Coiled-coil domain-containing protein 134
1_MDLLQ 6_ FLAFL 11_ FVLLL 16_ SGMGA 21_ TGTLR 26_ TSLDP 31_ SLEIY 36_ KKMFE 41_ VKRRE 46_ QLLAL 51_ KNLAQ 56_ LNDIH 61_ QQYKI 66_ LDVML 71_ KGLFK 76_ VLEDS 81_ RTVLT 86_ AADVL 91_ PDGPF 96_ PQDEK 101_ LKDAF 106_ SHVVE 111_ NTAFF 116_ GDVVL 121_ RFPRI 126_ VHYYF 131_ DHNSN 136_ WNLLI 141_ RWGIS 146_ FCNQT 151_ GVFNQ 156_ GPHSP 161_ ILSLM 166_ AQELG 171_ ISEKD 176_ SNFQN 181_ PFKID 186_ RTEFI 191_ PSTDP 196_ FQKAL 201_ REEEK 206_ RRKKE 211_ EKRKE 216_ IRKGP 221_RISRS
1: Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding (PubMed:38670073, PubMed:39509507). In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1 (PubMed:39509507). In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity (PubMed:22644376). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939)