Transcription factor SOX-17
1_MSSPD 6_ AGYAS 11_ DDQSQ 16_ TQSAL 21_ PAVMA 26_ GLGPC 31_ PWAES 36_ LSPIG 41_ DMKVK 46_ GEAPA 51_ NSGAP 56_ AGAAG 61_ RAKGE 66_ SRIRR 71_ PMNAF 76_ MVWAK 81_ DERKR 86_ LAQQN 91_ PDLHN 96_ AELSK 101_ MLGKS 106_ WKALT 111_ LAEKR 116_ PFVEE 121_ AERLR 126_ VQHMQ 131_ DHPNY 136_ KYRPR 141_ RRKQV 146_ KRLKR 151_ VEGGF 156_ LHGLA 161_ EPQAA 166_ ALGPE 171_ GGRVA 176_ MDGLG 181_ LQFPE 186_ QGFPA 191_ GPPLL 196_ PPHMG 201_ GHYRD 206_ CQSLG 211_ APPLD 216_ GYPLP 221_ TPDTS 226_ PLDGV 231_ DPDPA 236_ FFAAP 241_ MPGDC 246_ PAAGT 251_ YSYAQ 256_ VSDYA 261_ GPPEP 266_ PAGPM 271_ HPRLG 276_ PEPAG 281_ PSIPG 286_ LLAPP 291_ SALHV 296_ YYGAM 301_ GSPGA 306_ GGGRG 311_ FQMQP 316_ QHQHQ 321_ HQHQH 326_ HPPGP 331_ GQPSP 336_ PPEAL 341_ PCRDG 346_ TDPSQ 351_ PAELL 356_ GEVDR 361_ TEFEQ 366_ YLHFV 371_ CKPEM 376_ GLPYQ 381_ GHDSG 386_ VNLPD 391_ SHGAI 396_ SSVVS 401_ DASSA 406_VYYCN
1: Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells