Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein)
1_MEGMD 6_ VDLDP 11_ ELMQK 16_ FSCLG 21_ TTDKD 26_ VLISE 31_ FQRLL 36_ GFQLN 41_ PAGCA 46_ FFLDM 51_ TNWNL 56_ QAAIG 61_ AYYDF 66_ ESPNI 71_ SVPSM 76_ SFVED 81_ VTIGE 86_ GESIP 91_ PDTQF 96_ VKTWR 101_ IQNSG 106_ AEAWP 111_ PGVCL 116_ KYVGG 121_ DQFGH 126_ VNMVM 131_ VRSLE 136_ PQEIA 141_ DVSVQ 146_ MCSPS 151_ RAGMY 156_ QGQWR 161_ MCTAT 166_ GLYYG 171_ DVIWV 176_ ILSVE 181_ VGGLL 186_ GVTQQ 191_ LSSFE 196_ TEFNT 201_ QPHRK 206_ VEGNF 211_ NPFAS 216_ PQKNR 221_ QSDEN 226_ NLKDP 231_ GGSEF 236_ DSISK 241_ NTWAP 246_ APDTW 251_ APAPD 256_ QTEQD 261_ QNRLS 266_ QNSVN 271_ LSPSS 276_ HANNL 281_ SVVTY 286_ SKGLH 291_GPYPF
1: Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199)