Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta]
1_MTMEK 6_ GMSSG 11_ EGLPS 16_ RSSQV 21_ SAGKI 26_ TAKEL 31_ ETKQS 36_ YKEKR 41_ GGFVL 46_ VHAGA 51_ GYHSE 56_ SKAKE 61_ YKHVC 66_ KRACQ 71_ KAIEK 76_ LQAGA 81_ LATDA 86_ VTAAL 91_ VELED 96_ SPFTN 101_ AGMGS 106_ NLNLL 111_ GEIEC 116_ DASIM 121_ DGKSL 126_ NFGAV 131_ GALSG 136_ IKNPV 141_ SVANR 146_ LLCEG 151_ QKGKL 156_ SAGRI 161_ PPCFL 166_ VGEGA 171_ YRWAV 176_ DHGIP 181_ SCPPN 186_ IMTTR 191_ FSLAA 196_ FKRNK 201_ RKLEL 206_ AERVD 211_ TDFMQ 216_ LKKRR 221_ QSSEK 226_ ENDSG 231_ TLDTV 236_ GAVVV 241_ DHEGN 246_ VAAAV 251_ SSGGL 256_ ALKHP 261_ GRVGQ 266_ AALYG 271_ CGCWA 276_ ENTGA 281_ HNPYS 286_ TAVST 291_ SGCGE 296_ HLVRT 301_ ILARE 306_ CSHAL 311_ QAEDA 316_ HQALL 321_ ETMQN 326_ KFISS 331_ PFLAS 336_ EDGVL 341_ GGVIV 346_ LRSCR 351_ CSAEP 356_ DSSQN 361_ KQTLL 366_ VEFLW 371_ SHTTE 376_ SMCVG 381_ YMSAQ 386_ DGKAK 391_ THISR 396_ LPPGA 401_ VAGQS 406_ VAIEG 411_GVCRL
1: Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557)