ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33)
1_MPEEA 6_ GFPPA 11_ KRFRP 16_ GSGPP 21_ SRAGS 26_ FPPGR 31_ QVVML 36_ LTAGS 41_ GGRGG 46_ GGGRR 51_ QQPPL 56_ AQPSA 61_ SPYPE 66_ AVELQ 71_ RRSLP 76_ IFQAR 81_ GQLLA 86_ QLRNL 91_ DNAVL 96_ IGETG 101_ SGKTT 106_ QIPQY 111_ LYEGG 116_ ISRQG 121_ IIAVT 126_ QPRRV 131_ AAISL 136_ ATRVS 141_ DEKRT 146_ ELGKL 151_ VGYTV 156_ RFDDV 161_ TSEDT 166_ RIKFL 171_ TDGML 176_ LREAI 181_ SDSLL 186_ RKYSC 191_ VILDE 196_ AHERT 201_ IHTDV 206_ LFGVV 211_ KAAQK 216_ RRKEL 221_ GKLPL 226_ KVIVM 231_ SATMD 236_ VDLFS 241_ QYFNG 246_ APVLY 251_ LEGRQ 256_ HPIQV 261_ FYTKQ 266_ PQNDY 271_ LHAAL 276_ VSVFQ 281_ IHQEA 286_ PSSQD 291_ ILVFL 296_ TGQEE 301_ IEAMS 306_ KTCRD 311_ IAKHL 316_ PDGCP 321_ AMLVL 326_ PLYAS 331_ LPYAQ 336_ QLRVF 341_ QGAPK 346_ GYRKV 351_ IISTN 356_ IAETS 361_ ITITG 366_ IKYVV 371_ DTGMV 376_ KAKKY 381_ NPDSG 386_ LEVLA 391_ VQRVS 396_ KTQAW 401_ QRTGR 406_ AGRED 411_ SGICY 416_ RLYTE 421_ DEFEK 426_ FDKMT 431_ VPEIQ 436_ RCNLA 441_ SVMLQ 446_ LLAMK 451_ VPNVL 456_ TFDFM 461_ SKPSP 466_ DHIQA 471_ AIAQL 476_ DLLGA 481_ LEHKD 486_ DQLTL 491_ TPMGR 496_ KMAAF 501_ PLEPK 506_ FAKTI 511_ LMSPK 516_ FHCTE 521_ EILTI 526_ VSLLS 531_ VDSVL 536_ HNPPS 541_ RREEV 546_ QGVRK 551_ KFISS 556_ EGDHM 561_ TLLNI 566_ YRTFK 571_ NLGGN 576_ KDWCK 581_ ENFVN 586_ SKNMT 591_ LVAEV 596_ RAQLR 601_ DICLK 606_ MSMPI 611_ ASSRG 616_ DVESV 621_ RRCLA 626_ HSLFM 631_ STAEL 636_ QPDGT 641_ YATTD 646_ THQPV 651_ AIHPS 656_ SVLFH 661_ CKPAC 666_ VVYTE 671_ LLYTN 676_ KCYMR 681_ DLCVI 686_ DAQWL 691_ YEAAP 696_ EYFRR 701_KLRTA
1: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity)