Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)
1_MGTFC 6_ SVIKF 11_ ENLQE 16_ LKRLC 21_ HWGPI 26_ IALGV 31_ IAICS 36_ TMAMI 41_ DSVLW 46_ YWPLH 51_ TTGGS 56_ VNFIM 61_ LINWT 66_ VMILY 71_ NYFNA 76_ MFVGP 81_ GFVPL 86_ GWKPE 91_ ISQDT 96_ MYLQY 101_ CKVCQ 106_ AYKAP 111_ RSHHC 116_ RKCNR 121_ CVMKM 126_ DHHCP 131_ WINNC 136_ CGYQN 141_ HASFT 146_ LFLLL 151_ APLGC 156_ IHAAF 161_ IFVMT 166_ MYTQL 171_ YHRLS 176_ FGWNT 181_ VKIDM 186_ SAARR 191_ DPLPI 196_ VPFGL 201_ AAFAT 206_ TLFAL 211_ GLALG 216_ TTIAV 221_ GMLFF 226_ IQMKI 231_ ILRNK 236_ TSIES 241_ WIEEK 246_ AKDRI 251_ QYYQL 256_ DEVFV 261_ FPYDM 266_ GSRWR 271_ NFKQV 276_ FTWSG 281_ VPEGD 286_ GLEWP 291_ VREGC 296_ HQYSL 301_ TIEQL 306_ KQKAD 311_ KRVRS 316_ VRYKV 321_ IEDYS 326_ GACCP 331_ LNKGI 336_ KTFFT 341_ SPCTE 346_ EPRIQ 351_ LQKGE 356_ FILAT 361_ RGLRY 366_ WLYGD 371_ KILDD 376_ SFIEG 381_ VSRIR 386_ GWFPR 391_ KCVEK 396_ CPCDA 401_ ETDQA 406_PEGEK
1: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (PubMed:26214738)