3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)
1_MSRPS 6_ SVSPR 11_ QPAPG 16_ GGGGG 21_ GPSPC 26_ GPGGG 31_ GRAKG 36_ LKDIR 41_ IDEEV 46_ KIAVN 51_ IALER 56_ FRYGD 61_ QREME 66_ FPSSL 71_ TSTER 76_ AFIHR 81_ LSQSL 86_ GLVSK 91_ SKGKG 96_ ANRYL 101_ TVKKK 106_ DGSET 111_ AHAMM 116_ TCNLT 121_ HNTKH 126_ AVRSL 131_ IQRFP 136_ VTNKE 141_ RTELL 146_ PKTER 151_ GNVFA 156_ VEAEN 161_ REMSK 166_ TSGRL 171_ NNGIP 176_ QIPVK 181_ RGESE 186_ FDSFR 191_ QSLPV 196_ FEKQE 201_ EIVKI 206_ IKENK 211_ VVLIV 216_ GETGS 221_ GKTTQ 226_ IPQFL 231_ LDDCF 236_ KNGIP 241_ CRIFC 246_ TQPRR 251_ LAAIA 256_ VAERV 261_ AAERR 266_ ERIGQ 271_ TIGYQ 276_ IRLES 281_ RVSPK 286_ TLLTF 291_ CTNGV 296_ LLRTL 301_ MAGDS 306_ TLSTV 311_ THVIV 316_ DEVHE 321_ RDRFS 326_ DFLLT 331_ KLRDL 336_ LQKHP 341_ TLKLI 346_ LSSAA 351_ LDVNL 356_ FIRYF 361_ GSCPV 366_ IYIQG 371_ RPFEV 376_ KEMFL 381_ EDILR 386_ TTGYT 391_ NKEML 396_ KYKKE 401_ KQQEE 406_ KQQTT 411_ LTEWY 416_ SAQEN 421_ SFKPE 426_ SQRQR 431_ TVLNV 436_ TDEYD 441_ LLDDG 446_ GDAVF 451_ SQLTE 456_ KDVNC 461_ LEPWL 466_ IKEMD 471_ ACLSD 476_ IWLHK 481_ DIDAF 486_ AQVFH 491_ LILTE 496_ NVSVD 501_ YRHSE 506_ TSATA 511_ LMVAA 516_ GRGFA 521_ SQVEQ 526_ LISMG 531_ ANVHS 536_ KASNG 541_ WMALD 546_ WAKHF 551_ GQTEI 556_ VDLLE 561_ SYSAT 566_ LEFGN 571_ LDESS 576_ LVQTN 581_ GSDLS 586_ AEDRE 591_ LLKAY 596_ HHSFD 601_ DEKVD 606_ LDLIM 611_ HLLYN 616_ ICHSC 621_ DAGAV 626_ LIFLP 631_ GYDEI 636_ VGLRD 641_ RILFD 646_ DKRFA 651_ DSTHR 656_ YQVFM 661_ LHSNM 666_ QTSDQ 671_ KKVLK 676_ NPPAG 681_ VRKII 686_ LSTNI 691_ AETSI 696_ TVNDV 701_ VFVID 706_ SGKVK 711_ EKSFD 716_ ALNFV 721_ TMLKM 726_ VWISK 731_ ASAIQ 736_ RKGRA 741_ GRCRP 746_ GICFR 751_ LFSRL 756_ RFQNM 761_ LEFQT 766_ PELLR 771_ MPLQE 776_ LCLHT 781_ KLLAP 786_ VNCPI 791_ ADFLM 796_ KAPEP 801_ PPALI 806_ VRNAV 811_ QMLKT 816_ IDAMD 821_ TWEDL 826_ TELGY 831_ HLADL 836_ PVEPH 841_ LGKMV 846_ LCAVV 851_ LKCLD 856_ PILTI 861_ ACTLA 866_ YRDPF 871_ VLPTQ 876_ ASQKR 881_ AAMLC 886_ RKRFT 891_ AGAFS 896_ DHMAL 901_ LRAFQ 906_ AWQKA 911_ RSDGW 916_ ERAFC 921_ EKNFL 926_ SQATM 931_ EIIIG 936_ MRTQL 941_ LGQLR 946_ ASGFV 951_ RARGG 956_ GDIRD 961_ VNTNS 966_ ENWAV 971_ VKAAL 976_ VAGMY 981_ PNLVH 986_ VDREN 991_ LVLTG 996_ PKEKK 1001_ VRFHP 1006_ ASVLS 1011_ QPQYK 1016_ KIPPA 1021_ NGQAA 1026_ AIKAL 1031_ PTDWL 1036_ IYDEM 1041_ TRAHR 1046_ IANIR 1051_ CCSAV 1056_ TPVTI 1061_ LVFCG 1066_ PARLA 1071_ SNALQ 1076_ EPSSF 1081_ RVDGI 1086_ PNDSS 1091_ DSEME 1096_ DKTTA 1101_ NLAAL 1106_ KLDEW 1111_ LHFTL 1116_ EPEAA 1121_ SLLLQ 1126_ LRQKW 1131_ HSLFL 1136_ RRMRA 1141_ PSKPW 1146_ SQVDE 1151_ ATIRA 1156_ IIAVL 1161_ STEEQ 1166_ SAGLQ 1171_ QPSGI 1176_ GQRPR 1181_ PMSSE 1186_ ELPLA 1191_ SSWRS 1196_ NNSRK 1201_ SSADT 1206_ EFSDE 1211_ CTTAE 1216_ RVLMK 1221_ SPSPA 1226_ LHPPQ 1231_ KYKDR 1236_ GILHP 1241_ KRGTE 1246_ DRSDQ 1251_ SSLKS 1256_ TDSSS 1261_ YPSPC 1266_ ASPSP 1271_ PSSGK 1276_ GSKSP 1281_ SPRPN 1286_ MPVRY 1291_ FIMKS 1296_ SNLRN 1301_ LEISQ 1306_ QKGIW 1311_ STTPS 1316_ NERKL 1321_ NRAFW 1326_ ESSIV 1331_ YLVFS 1336_ VQGSG 1341_ HFQGF 1346_ SRMSS 1351_ EIGRE 1356_ KSQDW 1361_ GSAGL 1366_ GGVFK 1371_ VEWIR 1376_ KESLP 1381_ FQFAH 1386_ HLLNP 1391_ WNDNK 1396_ KVQIS 1401_ RDGQE 1406_ LEPLV 1411_ GEQLL 1416_ QLWER 1421_LPLGE
1: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity)