Lipid droplet-associated hydrolase (EC 3.1.1.-) (Lipid droplet-associated serine hydrolase) (hLDAH)
1_MDSEL 6_ KEEIP 11_ VHEEF 16_ ILCGG 21_ AETQV 26_ LKCGP 31_ WTDLF 36_ HDQSV 41_ KRPKL 46_ LIFII 51_ PGNPG 56_ FSAFY 61_ VPFAK 66_ ALYSL 71_ TNRRF 76_ PVWTI 81_ SHAGH 86_ ALAPK 91_ DKKIL 96_ TTSED 101_ SNAQE 106_ IKDIY 111_ GLNGQ 116_ IEHKL 121_ AFLRT 126_ HVPKD 131_ MKLVL 136_ IGHSI 141_ GSYFT 146_ LQMLK 151_ RVPEL 156_ PVIRA 161_ FLLFP 166_ TIERM 171_ SESPN 176_ GRIAT 181_ PLLCW 186_ FRYVL 191_ YVTGY 196_ LLLKP 201_ CPETI 206_ KSLLI 211_ RRGLQ 216_ VMNLE 221_ NEFSP 226_ LNILE 231_ PFCLA 236_ NAAYL 241_ GGQEM 246_ MEVVK 251_ RDDET 256_ IKEHL 261_ CKLTF 266_ YYGTI 271_ DPWCP 276_ KEYYE 281_ DIKKD 286_ FPEGD 291_ IRLCE 296_ KNIPH 301_ AFITH 306_ FNQEM 311_ ADMIA 316_DSLKD
1: Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity)