Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)
1_MDGLQ 6_ ASAGP 11_ LRRGR 16_ PKRRR 21_ KPQPH 26_ SGSVL 31_ ALPLR 36_ SRKIR 41_ KQLRS 46_ VVSRM 51_ AALRT 56_ QTLPS 61_ ENSEE 66_ SRVES 71_ TADDL 76_ GDALP 81_ GGAAV 86_ AAVPD 91_ AARRE 96_ PYGHL 101_ GPAEL 106_ LEASP 111_ AARSL 116_ QTPSA 121_ RLVPA 126_ SAPPA 131_ RLVEV 136_ PAAPV 141_ RVVET 146_ SALLC 151_ TAQHL 156_ AAVQS 161_ SGAPA 166_ TASGP 171_ QVDNT 176_ GGEPA 181_ WDSPL 186_ RRVLA 191_ ELNRI 196_ PSSRR 201_ RAARL 206_ FEWLI 211_ APMPP 216_ DHFYR 221_ RLWER 226_ EAVLV 231_ RRQDH 236_ TYYQG 241_ LFSTA 246_ DLDSM 251_ LRNEE 256_ VQFGQ 261_ HLDAA 266_ RYING 271_ RRETL 276_ NPPGR 281_ ALPAA 286_ AWSLY 291_ QAGCS 296_ LRLLC 301_ PQAFS 306_ TTVWQ 311_ FLAVL 316_ QEQFG 321_ SMAGS 326_ NVYLT 331_ PPNSQ 336_ GFAPH 341_ YDDIE 346_ AFVLQ 351_ LEGRK 356_ LWRVY 361_ RPRVP 366_ TEELA 371_ LTSSP 376_ NFSQD 381_ DLGEP 386_ VLQTV 391_ LEPGD 396_ LLYFP 401_ RGFIH 406_ QAECQ 411_ DGVHS 416_ LHLTL 421_ STYQR 426_ NTWGD 431_ FLEAI 436_ LPLAV 441_ QAAME 446_ ENVEF 451_ RRGLP 456_ RDFMD 461_ YMGAQ 466_ HSDSK 471_ DPRRT 476_ AFMEK 481_ VRVLV 486_ ARLGH 491_ FAPVD 496_ AVADQ 501_ RAKDF 506_ IHDSL 511_ PPVLT 516_ DRERA 521_ LSVYG 526_ LPIRW 531_ EAGEP 536_ VNVGA 541_ QLTTE 546_ TEVHM 551_ LQDGI 556_ ARLVG 561_ EGGHL 566_ FLYYT 571_ VENSR 576_ VYHLE 581_ EPKCL 586_ EIYPQ 591_ QADAM 596_ ELLLG 601_ SYPEF 606_ VRVGD 611_ LPCDS 616_ VEDQL 621_ SLATT 626_ LYDKG 631_ LLLTK 636_MPLAL
1: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053)