Anthrax toxin receptor 1 (Tumor endothelial marker 8)
1_MATAE 6_ RRALG 11_ IGFQW 16_ LSLAT 21_ LVLIC 26_ AGQGG 31_ RREDG 36_ GPACY 41_ GGFDL 46_ YFILD 51_ KSGSV 56_ LHHWN 61_ EIYYF 66_ VEQLA 71_ HKFIS 76_ PQLRM 81_ SFIVF 86_ STRGT 91_ TLMKL 96_ TEDRE 101_ QIRQG 106_ LEELQ 111_ KVLPG 116_ GDTYM 121_ HEGFE 126_ RASEQ 131_ IYYEN 136_ RQGYR 141_ TASVI 146_ IALTD 151_ GELHE 156_ DLFFY 161_ SEREA 166_ NRSRD 171_ LGAIV 176_ YCVGV 181_ KDFNE 186_ TQLAR 191_ IADSK 196_ DHVFP 201_ VNDGF 206_ QALQG 211_ IIHSI 216_ LKKSC 221_ IEILA 226_ AEPST 231_ ICAGE 236_ SFQVV 241_ VRGNG 246_ FRHAR 251_ NVDRV 256_ LCSFK 261_ INDSV 266_ TLNEK 271_ PFSVE 276_ DTYLL 281_ CPAPI 286_ LKEVG 291_ MKAAL 296_ QVSMN 301_ DGLSF 306_ ISSSV 311_ IITTT 316_ HCSDG 321_ SILAI 326_ ALLIL 331_ FLLLA 336_ LALLW 341_ WFWPL 346_ CCTVI 351_ IKEVP 356_ PPPAE 361_ ESEEE 366_ DDDGL 371_ PKKKW 376_ PTVDA 381_ SYYGG 386_ RGVGG 391_ IKRME 396_ VRWGE 401_ KGSTE 406_ EGAKL 411_ EKAKN 416_ ARVKM 421_ PEQEY 426_ EFPEP 431_ RNLNN 436_ NMRRP 441_ SSPRK 446_ WYSPI 451_ KGKLD 456_ ALWVL 461_ LRKGY 466_ DRVSV 471_ MRPQP 476_ GDTGR 481_ CINFT 486_ RVKNN 491_ QPAKY 496_ PLNNA 501_ YHTSS 506_ PPPAP 511_ IYTPP 516_ PPAPH 521_ CPPPP 526_ PSAPT 531_ PPIPS 536_ PPSTL 541_ PPPPQ 546_ APPPN 551_ RAPPP 556_SRPPP
1: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478)
2: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis
3: (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated