E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) (RING-type E3 ubiquitin transferase RNF167) (RING105)
1_MHPAA 6_ FPLPV 11_ VVAAV 16_ LWGAA 21_ PTRGL 26_ IRATS 31_ DHNAS 36_ MDFAD 41_ LPALF 46_ GATLS 51_ QEGLQ 56_ GFLVE 61_ AHPDN 66_ ACSPI 71_ APPPP 76_ APVNG 81_ SVFIA 86_ LLRRF 91_ DCNFD 96_ LKVLN 101_ AQKAG 106_ YGAAV 111_ VHNVN 116_ SNELL 121_ NMVWN 126_ SEEIQ 131_ QQIWI 136_ PSVFI 141_ GERSS 146_ EYLRA 151_ LFVYE 156_ KGARV 161_ LLVPD 166_ NTFPL 171_ GYYLI 176_ PFTGI 181_ VGLLV 186_ LAMGA 191_ VMIAR 196_ CIQHR 201_ KRLQR 206_ NRLTK 211_ EQLKQ 216_ IPTHD 221_ YQKGD 226_ QYDVC 231_ AICLD 236_ EYEDG 241_ DKLRV 246_ LPCAH 251_ AYHSR 256_ CVDPW 261_ LTQTR 266_ KTCPI 271_ CKQPV 276_ HRGPG 281_ DEDQE 286_ EETQG 291_ QEEGD 296_ EGEPR 301_ DHPAS 306_ ERTPL 311_ LGSSP 316_ TLPTS 321_ FGSLA 326_ PAPLV 331_ FPGPS 336_ TDPPL 341_SPPSS
1: E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289)