Ran-binding protein 3 (RanBP3)
1_MADLA 6_ NEEKP 11_ AIAPP 16_ VFVFQ 21_ KDKGQ 26_ KSPAE 31_ QKNLS 36_ DSGEE 41_ PRGEA 46_ EAPHH 51_ GTGHP 56_ ESAGE 61_ HALEP 66_ PAPAG 71_ ASAST 76_ PPPPA 81_ PEAQL 86_ PPFPR 91_ ELAGR 96_ SAGGS 101_ SPEGG 106_ EDSDR 111_ EDGNY 116_ CPPVK 121_ RERTS 126_ SLTQF 131_ PPSQS 136_ EERSS 141_ GFRLK 146_ PPTLI 151_ HGQAP 156_ SAGLP 161_ SQKPK 166_ EQQRS 171_ VLRPA 176_ VLQAP 181_ QPKAL 186_ SQTVP 191_ SSGTN 196_ GVSLP 201_ ADCTG 206_ AVPAA 211_ SPDTA 216_ AWRSP 221_ SEAAD 226_ EVCAL 231_ EEKEP 236_ QKNES 241_ SNASE 246_ EEACE 251_ KKDPA 256_ TQQAF 261_ VFGQN 266_ LRDRV 271_ KLINE 276_ SVDEA 281_ DMENA 286_ GHPSA 291_ DTPTA 296_ TNYFL 301_ QYISS 306_ SLENS 311_ TNSAD 316_ ASSNK 321_ FVFGQ 326_ NMSER 331_ VLSPP 336_ KLNEV 341_ SSDAN 346_ RENAA 351_ AESGS 356_ ESSSQ 361_ EATPE 366_ KESLA 371_ ESAAA 376_ YTKAT 381_ ARKCL 386_ LEKVE 391_ VITGE 396_ EAESN 401_ VLQMQ 406_ CKLFV 411_ FDKTS 416_ QSWVE 421_ RGRGL 426_ LRLND 431_ MASTD 436_ DGTLQ 441_ SRLVM 446_ RTQGS 451_ LRLIL 456_ NTKLW 461_ AQMQI 466_ DKASE 471_ KSIRI 476_ TAMDT 481_ EDQGV 486_ KVFLI 491_ SASSK 496_ DTGQL 501_ YAALH 506_ HRILA 511_ LRSRV 516_ EQEQE 521_ AKMPA 526_ PEPGA 531_ APSNE 536_ EDDSD 541_ DDDVL 546_ APSGA 551_ TAAGA 556_ GDEGD 561_GQTTG
1: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export