Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like)
1_MVSQS 6_ TVRQD 11_ SPVEP 16_ WEGIS 21_ DHSGI 26_ IDGSP 31_ RLLNT 36_ DHPPC 41_ QLDIR 46_ LMRHK 51_ AVWIN 56_ PQDVQ 61_ QQPQD 66_ LQSQV 71_ PAAGN 76_ SGTHF 81_ VTDAA 86_ SPSGP 91_ SPSCL 96_ GDSLA 101_ ETTLS 106_ EDTTD 111_ SVGSA 116_ SPHGS 121_ SEKSS 126_ SFSLS 131_ STEVH 136_ MVRPG 141_ YSHRV 146_ SLPTS 151_ PGILA 156_ TSPYP 161_ ETDSA 166_ FFEPS 171_ HLTSA 176_ ADEGA 181_ VQVSR 186_ RTISS 191_ NSFSP 196_ EVFVL 201_ PVDVE 206_ KENAH 211_ FYVAD 216_ MIISA 221_ MEKMK 226_ CNILS 231_ QQQTE 236_ SWSKE 241_ VSGLL 246_ GSDQP 251_ DSEMT 256_ FDTNI 261_ KQESG 266_ SSTSS 271_ YSGYE 276_ GCAVL 281_ QVSPV 286_ TETRT 291_ YHDVK 296_ EICKC 301_ DVDEF 306_ VILEL 311_ GDFND 316_ ITETC 321_ SCSCS 326_ SSKSV 331_ TYEPD 336_ FNSAE 341_ LLAKE 346_ LYRVF 351_ QKCWI 356_ LSVVN 361_ SQLAG 366_ SLSAA 371_ GSIVV 376_ NEECV 381_ RKDFE 386_ SSMNV 391_ VQEIK 396_ FKSRI 401_ RGTED 406_ WAPPR 411_ FQIIF 416_ NIHPP 421_ LKRDL 426_ VVAAQ 431_ NFFCA 436_ GCGTP 441_ VEPKF 446_ VKRLR 451_ YCEYL 456_ GKYFC 461_ DCCHS 466_ YAESC 471_ IPARI 476_ LMMWD 481_ FKKYY 486_ VSNFS 491_ KQLLD 496_ SIWHQ 501_ PIFNL 506_ LSIGQ 511_ SLYAK 516_ AKELD 521_ RVKEI 526_ QEQLF 531_ HIKKL 536_ LKTCR 541_ FANSA 546_ LKEFE 551_ QVPGH 556_ LTDEL 561_ HLFSL 566_ EDLVR 571_ IKKGL 576_ LAPLL 581_ KDILK 586_ ASLAH 591_ VAGCE 596_ LCQGK 601_ GFICE 606_ FCQNT 611_ TVIFP 616_ FQTAT 621_ CRRCS 626_ ACRAC 631_ FHKQC 636_ FQSSE 641_ CPRCA 646_ RITAR 651_ RKLLE 656_SVASA
1: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable)