Leucine-rich repeat-containing protein 19
1_MKVTG 6_ ITILF 11_ WPLSM 16_ ILLSD 21_ KIQSS 26_ KREVQ 31_ CNFTE 36_ KNYTL 41_ IPADI 46_ KKDVT 51_ ILDLS 56_ YNQIT 61_ LNGTD 66_ TRVLQ 71_ TYFLL 76_ TELYL 81_ IENKV 86_ TILHN 91_ NGFGN 96_ LSSLE 101_ ILNIC 106_ RNSIY 111_ VIQQG 116_ AFLGL 121_ NKLKQ 126_ LYLCQ 131_ NKIEQ 136_ LNADV 141_ FVPLR 146_ SLKLL 151_ NLQGN 156_ LISYL 161_ DVPPL 166_ FHLEL 171_ ITLYG 176_ NLWNC 181_ SCSLF 186_ NLQNW 191_ LNTSN 196_ VTLEN 201_ ENITM 206_ CSYPN 211_ SLQSY 216_ NIKTV 221_ PHKAE 226_ CHSKF 231_ PSSVT 236_ EDLYI 241_ HFQPI 246_ SNSIF 251_ NSSSN 256_ NLTRN 261_ SEHEP 266_ LGKSW 271_ AFLVG 276_ VVVTV 281_ LTTSL 286_ LIFIA 291_ IKCPI 296_ WYNIL 301_ LSYNH 306_ HRLEE 311_ HEAET 316_ YEDGF 321_ TGNPS 326_ SLSQI 331_ PETNS 336_ EETTV 341_ IFEQL 346_ HSFVV 351_ DDDGF 356_ IEDKY 361_IDIHE
1: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity)