Ankyrin repeat and SOCS box protein 8 (ASB-8)
1_MSSSM 6_ WYIMQ 11_ SIQSK 16_ YSLSE 21_ RLIRT 26_ IAAIR 31_ SFPHD 36_ NVEDL 41_ IRGGA 46_ DVNCT 51_ HGTLK 56_ PLHCA 61_ CMVSD 66_ ADCVE 71_ LLLEK 76_ GAEVN 81_ ALDGY 86_ NRTAL 91_ HYAAE 96_ KDEAC 101_ VEVLL 106_ EYGAN 111_ PNALD 116_ GNRDT 121_ PLHWA 126_ AFKNN 131_ AECVR 136_ ALLES 141_ GASVN 146_ ALDYN 151_ NDTPL 156_ SWAAM 161_ KGNLE 166_ SVSIL 171_ LDYGA 176_ EVRVI 181_ NLIGQ 186_ TPISR 191_ LVALL 196_ VRGLG 201_ TEKED 206_ SCFEL 211_ LHRAV 216_ GHFEL 221_ RKNGT 226_ MPREV 231_ ARDPQ 236_ LCEKL 241_ TVLCS 246_ APGTL 251_ KTLAR 256_ YAVRR 261_ SLGLQ 266_ YLPDA 271_ VKGLP 276_ LPASL 281_KEYLL
1: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation (PubMed:32298923)