Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1)
1_MSMDV 6_ TFLGT 11_ GAAYP 16_ SPTRG 21_ ASAVV 26_ LRCEG 31_ ECWLF 36_ DCGEG 41_ TQTQL 46_ MKSQL 51_ KAGRI 56_ TKIFI 61_ THLHG 66_ DHFFG 71_ LPGLL 76_ CTISL 81_ QSGSM 86_ VSKQP 91_ IEIYG 96_ PVGLR 101_ DFIWR 106_ TMELS 111_ HTELV 116_ FHYVV 121_ HELVP 126_ TADQC 131_ PAEEL 136_ KEFAH 141_ VNRAD 146_ SPPKE 151_ EQGRT 156_ ILLDS 161_ EENSY 166_ LLFDD 171_ EQFVV 176_ KAFRL 181_ FHRIP 186_ SFGFS 191_ VVEKK 196_ RPGKL 201_ NAQKL 206_ KDLGV 211_ PPGPA 216_ YGKLK 221_ NGISV 226_ VLENG 231_ VTISP 236_ QDVLK 241_ KPIVG 246_ RKICI 251_ LGDCS 256_ GVVGD 261_ GGVKL 266_ CFEAD 271_ LLIHE 276_ ATLDD 281_ AQMDK 286_ AKEHG 291_ HSTPQ 296_ MAATF 301_ AKLCR 306_ AKRLV 311_ LTHFS 316_ QRYKP 321_ VALAR 326_ EGETD 331_ GIAEL 336_ KKQAE 341_ SVLDL 346_ QEVTL 351_ AEDFM 356_VISIP
1: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:12711671, PubMed:32075755). Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 (PubMed:32075755). tRNAs are then processed by TRNT1 (PubMed:32075755)