Exonuclease V (Exo V) (hExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog)
1_MAETR 6_ EEETV 11_ SAEAS 16_ GFSDL 21_ SDSEF 26_ LEFLD 31_ LEDAQ 36_ ESKAL 41_ VNMPG 46_ PSSES 51_ LGKDD 56_ KPISL 61_ QNWKR 66_ GLDIL 71_ SPMER 76_ FHLKY 81_ LYVTD 86_ LATQN 91_ WCELQ 96_ TAYGK 101_ ELPGF 106_ LAPEK 111_ AAVLD 116_ TGASI 121_ HLARE 126_ LELHD 131_ LVTVP 136_ VTTKE 141_ DAWAI 146_ KFLNI 151_ LLLIP 156_ TLQSE 161_ GHIRE 166_ FPVFG 171_ EGEGV 176_ LLVGV 181_ IDELH 186_ YTAKG 191_ ELELA 196_ ELKTR 201_ RRPML 206_ PLEAQ 211_ KKKDC 216_ FQVSL 221_ YKYIF 226_ DAMVQ 231_ GKVTP 236_ ASLIH 241_ HTKLC 246_ LEKPL 251_ GPSVL 256_ RHAQQ 261_ GGFSV 266_ KSLGD 271_ LMELV 276_ FLSLT 281_ LSDLP 286_ VIDIL 291_ KIEYI 296_ HQETA 301_ TVLGT 306_ EIVAF 311_ KEKEV 316_ RAKVQ 321_ HYMAY 326_ WMGHR 331_ EPQGV 336_ DVEEA 341_ WKCRT 346_ CTYAD 351_ ICEWR 356_ KGSGV 361_ LSSTL 366_APQVK
1: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity