Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1)
1_MEPLK 6_ VEKFA 11_ TAKRG 16_ NGLRA 21_ VTPLR 26_ PGELL 31_ FRSDP 36_ LAYTV 41_ CKGSR 46_ GVVCD 51_ RCLLG 56_ KEKLM 61_ RCSQC 66_ RVAKY 71_ CSAKC 76_ QKKAW 81_ PDHKR 86_ ECKCL 91_ KSCKP 96_ RYPPD 101_ SVRLL 106_ GRVVF 111_ KLMDG 116_ APSES 121_ EKLYS 126_ FYDLE 131_ SNINK 136_ LTEDK 141_ KEGLR 146_ QLVMT 151_ FQHFM 156_ REEIQ 161_ DASQL 166_ PPAFD 171_ LFEAF 176_ AKVIC 181_ NSFTI 186_ CNAEM 191_ QEVGV 196_ GLYPS 201_ ISLLN 206_ HSCDP 211_ NCSIV 216_ FNGPH 221_ LLLRA 226_ VRDIE 231_ VGEEL 236_ TICYL 241_ DMLMT 246_ SEERR 251_ KQLRD 256_ QYCFE 261_ CDCFR 266_ CQTQD 271_ KDADM 276_ LTGDE 281_ QVWKE 286_ VQESL 291_ KKIEE 296_ LKAHW 301_ KWEQV 306_ LAMCQ 311_ AIISS 316_ NSERL 321_ PDINI 326_ YQLKV 331_ LDCAM 336_ DACIN 341_ LGLLE 346_ EALFY 351_ GTRTM 356_ EPYRI 361_ FFPGS 366_ HPVRG 371_ VQVMK 376_ VGKLQ 381_ LHQGM 386_ FPQAM 391_ KNLRL 396_ AFDIM 401_ RVTHG 406_ REHSL 411_ IEDLI 416_ LLLEE 421_CDANI
1: Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609)