WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)
1_MQANG 6_ AGGGG 11_ GGGGG 16_ GGGGG 21_ GGGGG 26_ QGQTP 31_ ELACL 36_ SAQNG 41_ ESSPS 46_ SSSSA 51_ GDLAH 56_ ANGLL 61_ PSAPS 66_ AASNN 71_ SNSLN 76_ VNNGV 81_ PGGAA 86_ AASSA 91_ TVAAA 96_ SATTA 101_ ASSSL 106_ ATPEL 111_ GSSLK 116_ KKKRL 121_ SQSDE 126_ DVIRL 131_ IGQHL 136_ NGLGL 141_ NQTVD 146_ LLMQE 151_ SGCRL 156_ EHPSA 161_ TKFRN 166_ HVMEG 171_ DWDKA 176_ ENDLN 181_ ELKPL 186_ VHSPH 191_ AIVVR 196_ GALEI 201_ SQTLL 206_ GIIVR 211_ MKFLL 216_ LQQKY 221_ LEYLE 226_ DGKVL 231_ EALQV 236_ LRCEL 241_ TPLKY 246_ NTERI 251_ HVLSG 256_ YLMCS 261_ HAEDL 266_ RAKAE 271_ WEGKG 276_ TASRS 281_ KLLDK 286_ LQTYL 291_ PPSVM 296_ LPPRR 301_ LQTLL 306_ RQAVE 311_ LQRDR 316_ CLYHN 321_ TKLDN 326_ NLDSV 331_ SLLID 336_ HVCSR 341_ RQFPC 346_ YTQQI 351_ LTEHC 356_ NEVWF 361_ CKFSN 366_ DGTKL 371_ ATGSK 376_ DTTVI 381_ IWQVD 386_ PDTHL 391_ LKLLK 396_ TLEGH 401_ AYGVS 406_ YIAWS 411_ PDDNY 416_ LVACG 421_ PDDCS 426_ ELWLW 431_ NVQTG 436_ ELRTK 441_ MSQSH 446_ EDSLT 451_ SVAWN 456_ PDGKR 461_ FVTGG 466_ QRGQF 471_ YQCDL 476_ DGNLL 481_ DSWEG 486_ VRVQC 491_ LWCLS 496_ DGKTV 501_ LASDT 506_ HQRIR 511_ GYNFE 516_ DLTDR 521_ NIVQE 526_ DHPIM 531_ SFTIS 536_ KNGRL 541_ ALLNV 546_ ATQGV 551_ HLWDL 556_ QDRVL 561_ VRKYQ 566_ GVTQG 571_ FYTIH 576_ SCFGG 581_ HNEDF 586_ IASGS 591_ EDHKV 596_ YIWHK 601_ RSELP 606_ IAELT 611_ GHTRT 616_ VNCVS 621_ WNPQI 626_ PSMMA 631_ SASDD 636_ GTVRI 641_ WGPAP 646_ FIDHQ 651_ NIEEE 656_CSSMD
1: G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:26895380, PubMed:27098453). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity)