Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)
1_MSAAG 6_ LLAPA 11_ PAQAG 16_ APPAP 21_ EYYPE 26_ EDEEL 31_ ESAED 36_ DERSC 41_ RGRES 46_ DEDTE 51_ DASET 56_ DLAKH 61_ DEEDY 66_ VEMKE 71_ QMYQD 76_ KLASL 81_ KRQLQ 86_ QLQEG 91_ TLQEY 96_ QKRMK 101_ KLDQQ 106_ YKERI 111_ RNAEL 116_ FLQLE 121_ TEQVE 126_ RNYIK 131_ EKKAA 136_ VKEFE 141_ DKKVE 146_ LKENL 151_ IAELE 156_ EKKKM 161_ IENEK 166_ LTMEL 171_ TGDSM 176_ EVKPI 181_ MTRKL 186_ RRRPN 191_ DPVPI 196_ PDKRR 201_ KPAPA 206_ QLNYL 211_ LTDEQ 216_ IMEDL 221_ RTLNK 226_ LKSPK 231_ RPASP 236_ SSPEH 241_ LPATP 246_ AESPA 251_ QRFEA 256_ RIEDG 261_ KLYYD 266_ KRWYH 271_ KSQAI 276_ YLESK 281_ DNQKL 286_ SCVIS 291_ SVGAN 296_ EIWVR 301_ KTSDS 306_ TKMRI 311_ YLGQL 316_ QRGLF 321_VIRRR
1: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes