Aurora kinase A and ninein-interacting protein (AIBp)
1_MRRTG 6_ PEEEA 11_ CGVWL 16_ DAAAL 21_ KRRKV 26_ QTHLI 31_ KPGTK 36_ MLTLL 41_ PGERK 46_ ANIYF 51_ TQRRA 56_ PSTGI 61_ HQRSI 66_ ASFFT 71_ LQPGK 76_ TNGSD 81_ QKSVS 86_ SHTES 91_ QINKE 96_ SKKNA 101_ TQLDH 106_ LIPGL 111_ AHDCM 116_ ASPLA 121_ TSTTA 126_ DIQEA 131_ GLSPQ 136_ SLQTS 141_ GHHRM 146_ KTPFS 151_ TELSL 156_ LQPDT 161_ PDCAG 166_ DSHTP 171_ LAFSF 176_ TEDLE 181_ SSCLL 186_ DRKEE 191_ KGDSA 196_ RKWEW 201_ LHESK 206_ KNYQS 211_ MEKHT 216_ KLPGD 221_ KCCQP 226_ LGKTK 231_ LERKV 236_ SAKEN 241_ RQAPV 246_ LLQTY 251_ RESWN 256_ GENIE 261_ SVKQS 266_ RSPVS 271_ VFSWD 276_ NEKND 281_ KDSWS 286_ QLFTE 291_ DSQGQ 296_ RVIAH 301_ NTRAP 306_ FQDVT 311_ NNWNW 316_ DLGPF 321_ PNSPW 326_ AQCQE 331_ DGPTQ 336_ NLKPD 341_ LLFTQ 346_ DSEGN 351_QVIRH
1: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670)