N-alpha-acetyltransferase 60 (hNaa60) (EC 2.3.1.259) (Histone acetyltransferase type B protein 4) (HAT4) (EC 2.3.1.48) (N-acetyltransferase 15) (N-alpha-acetyltransferase F) (NatF)
1_MTEVV 6_ PSSAL 11_ SEVSL 16_ RLLCH 21_ DDIDT 26_ VKHLC 31_ GDWFP 36_ IEYPD 41_ SWYRD 46_ ITSNK 51_ KFFSL 56_ AATYR 61_ GAIVG 66_ MIVAE 71_ IKNRT 76_ KIHKE 81_ DGDIL 86_ ASNFS 91_ VDTQV 96_ AYILS 101_ LGVVK 106_ EFRKH 111_ GIGSL 116_ LLESL 121_ KDHIS 126_ TTAQD 131_ HCKAI 136_ YLHVL 141_ TTNNT 146_ AINFY 151_ ENRDF 156_ KQHHY 161_ LPYYY 166_ SIRGV 171_ LKDGF 176_ TYVLY 181_ INGGH 186_ PPWTI 191_ LDYIQ 196_ HLGSA 201_ LASLS 206_ PCSIP 211_ HRVYR 216_ QAHSL 221_ LCSFL 226_ PWSGI 231_ SSKSG 236_IEYSR
1: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826, PubMed:38480682). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27320834, PubMed:27550639). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917)