Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog)
1_MALFP 6_ AFAGL 11_ SEAPD 16_ GGSSR 21_ KELDW 26_ LSNPS 31_ FCVGS 36_ ITSLS 41_ QQTEA 46_ APAHV 51_ SEGLP 56_ LTRSH 61_ LKSES 66_ SDESD 71_ TNKKL 76_ KQTSR 81_ KKKKE 86_ KKKKR 91_ KHQHH 96_ KKTKR 101_ KHGPS 106_ SSSRS 111_ ETDTD 116_ SEKDK 121_ PSRGV 126_ GGSKK 131_ ESEEP 136_ NQGNN 141_ AAADT 146_ GHRFV 151_ WLEDI 156_ QAVTG 161_ ETFRT 166_ DKKPD 171_ PANWE 176_ YKSLY 181_ RGDIA 186_ RYKRK 191_ GDSCL 196_ GINPK 201_ KQCIS 206_ WEGTS 211_ TEKKH 216_ SRKQV 221_ ERYFT 226_ KKSVG 231_ LMNID 236_ GVAIS 241_ SKTEP 246_ PSSEP 251_ ISFIP 256_ VKDLE 261_ DAAPV 266_ TTWLN 271_ PLGIY 276_ DQSTT 281_ HWLQG 286_ QGPPE 291_ QESKQ 296_ PDAQP 301_ DSESA 306_ ALKAK 311_ VEEFN 316_ RRVRE 321_ NPRDT 326_ QLWMA 331_ FVAFQ 336_ DEVMK 341_ SPGLY 346_ AIEEG 351_ EQEKR 356_ KRSLK 361_ LILEK 366_ KLAIL 371_ ERAIE 376_ SNQSS 381_ VDLKL 386_ AKLKL 391_ CTEFW 396_ EPSTL 401_ VKEWQ 406_ KLIFL 411_ HPNNT 416_ ALWQK 421_ YLLFC 426_ QSQFS 431_ TFSIS 436_ KIHSL 441_ YGKCL 446_ STLSA 451_ VKDGS 456_ ILSHP 461_ ALPGT 466_ EEAMF 471_ ALFLQ 476_ QCHFL 481_ RQAGH 486_ SEKAI 491_ SLFQA 496_ MVDFT 501_ FFKPD 506_ SVKDL 511_ PTKGQ 516_ VEFFE 521_ PFWDS 526_ GEPRA 531_ GEKGA 536_ RGWKA 541_ WMHQQ 546_ ERGGW 551_ VVINP 556_ DEDDD 561_ EPEED 566_ DQEIK 571_ DKTLP 576_ RWQIW 581_ LAAER 586_ SRDQR 591_ HWRPW 596_ RPDKT 601_ KKQTE 606_ EDCED 611_ PERQV 616_ LFDDI 621_ GQSLI 626_ RLSSH 631_ DLQFQ 636_ LVEAF 641_ LQFLG 646_ VPSGF 651_ TPPAS 656_ CLYLA 661_ MDENS 666_ IFDNG 671_ LYDEK 676_ PLTFF 681_ NPLFS 686_ GASCV 691_ GRMDR 696_ LGYPR 701_ WTRGQ 706_ NREGE 711_ EFIRN 716_ VFHLV 721_ MPLFS 726_ GKEKS 731_ QLCFS 736_ WLQYE 741_ IAKVI 746_ WCLHT 751_ KNKKR 756_ LKSQG 761_ KNCKK 766_ LAKNL 771_ LKEPE 776_ NCNNF 781_ CLWKQ 786_ YAHLE 791_ WLLGN 796_ TEDAR 801_ KVFDT 806_ ALGMA 811_ GSREL 816_ KDSDL 821_ CELSL 826_ LYAEL 831_ EVELS 836_ PEVRR 841_ AATAR 846_ AVHIL 851_ TKLTE 856_ SSPYG 861_ PYTGQ 866_ VLAVH 871_ ILKAR 876_ KAYEH 881_ ALQDC 886_ LGDSC 891_ VSNPA 896_ PTDSC 901_ SRLIS 906_ LAKCF 911_ MLFQY 916_ LTIGI 921_ DAAVQ 926_ IYEQV 931_ FAKLN 936_ SSVFP 941_ EGSGE 946_ GDSAS 951_ SQSWT 956_ SVLEA 961_ ITLMH 966_ TSLLR 971_ FHMKV 976_ SVYPL 981_ APLRE 986_ ALSQA 991_ LKLYP 996_ GNQVL 1001_ WRSYV 1006_ QIQNK 1011_ SHSAS 1016_ KTRRF 1021_ FDTIT 1026_ RSAKP 1031_ LEPWL 1036_ FAIEA 1041_ EKLRK 1046_ RLVET 1051_ VQRLD 1056_ GREIH 1061_ ATIPE 1066_ TGLMH 1071_ RIQAL 1076_ FENAM 1081_ RSDSG 1086_ SQCPL 1091_ LWRMY 1096_ LNFLV 1101_ SLGNK 1106_ ERSKG 1111_ VFYKA 1116_ LQNCP 1121_ WAKVL 1126_ YLDAV 1131_ EYFPD 1136_ EMQEI 1141_ LDLMT 1146_ EKELR 1151_ VRLPL 1156_EELEL
1: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117)