Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)
1_MAAQG 6_ AAAAV 11_ AAGTS 16_ GVAGE 21_ GEPGP 26_ GENAA 31_ AEGTA 36_ PSPGR 41_ VSPPT 46_ PARGE 51_ PEVTV 56_ EIGET 61_ YLCRR 66_ PDSTW 71_ HSAEV 76_ IQSRV 81_ NDQEG 86_ REEFY 91_ VHYVG 96_ FNRRL 101_ DEWVD 106_ KNRLA 111_ LTKTV 116_ KDAVQ 121_ KNSEK 126_ YLSEL 131_ AEQPE 136_ RKITR 141_ NQKRK 146_ HDEIN 151_ HVQKT 156_ YAEMD 161_ PTTAA 166_ LEKEH 171_ EAITK 176_ VKYVD 181_ KIHIG 186_ NYEID 191_ AWYFS 196_ PFPED 201_ YGKQP 206_ KLWLC 211_ EYCLK 216_ YMKYE 221_ KSYRF 226_ HLGQC 231_ QWRQP 236_ PGKEI 241_ YRKSN 246_ ISVYE 251_ VDGKD 256_ HKIYC 261_ QNLCL 266_ LAKLF 271_ LDHKT 276_ LYFDV 281_ EPFVF 286_ YILTE 291_ VDRQG 296_ AHIVG 301_ YFSKE 306_ KESPD 311_ GNNVA 316_ CILTL 321_ PPYQR 326_ RGYGK 331_ FLIAF 336_ SYELS 341_ KLEST 346_ VGSPE 351_ KPLSD 356_ LGKLS 361_ YRSYW 366_ SWVLL 371_ EILRD 376_ FRGTL 381_ SIKDL 386_ SQMTS 391_ ITQND 396_ IISTL 401_ QSLNM 406_ VKYWK 411_ GQHVI 416_ CVTPK 421_ LVEEH 426_ LKSAQ 431_ YKKPP 436_ ITVDS 441_ VCLKW 446_ APPKH 451_KQVKL
1: Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206)