Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form]
1_MDPAA 6_ RVVRA 11_ LWPGG 16_ CALAW 21_ RLGGR 26_ PQPLL 31_ PTQSR 36_ AGFAG 41_ AAGGP 46_ SPVAA 51_ ARKGS 56_ PRLLG 61_ AAALA 66_ LGGAL 71_ GLYHT 76_ ARWHL 81_ RAQDL 86_ HAERS 91_ AAQLS 96_ LSSRL 101_ QLTLY 106_ QYKTC 111_ PFCSK 116_ VRAFL 121_ DFHAL 126_ PYQVV 131_ EVNPV 136_ RRAEI 141_ KFSSY 146_ RKVPI 151_ LVAQE 156_ GESSQ 161_ QLNDS 166_ SVIIS 171_ ALKTY 176_ LVSGQ 181_ PLEEI 186_ ITYYP 191_ AMKAV 196_ NEQGK 201_ EVTEF 206_ GNKYW 211_ LMLNE 216_ KEAQQ 221_ VYGGK 226_ EARTE 231_ EMKWR 236_ QWADD 241_ WLVHL 246_ ISPNV 251_ YRTPT 256_ EALAS 261_ FDYIV 266_ REGKF 271_ GAVEG 276_ AVAKY 281_ MGAAA 286_ MYLIS 291_ KRLKS 296_ RHRLQ 301_ DNVRE 306_ DLYEA 311_ ADKWV 316_ AAVGK 321_ DRPFM 326_ GGQKP 331_ NLADL 336_ AVYGV 341_ LRVME 346_ GLDAF 351_ DDLMQ 356_ HTHIQ 361_ PWYLR 366_ VERAI 371_TEASP
1: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783)