Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206)
1_MIRQE 6_ RSTSY 11_ QELSE 16_ ELVQV 21_ VENSE 26_ LADEQ 31_ DKETV 36_ RVQGP 41_ GILPG 46_ LDSES 51_ ASSSI 56_ RFSKA 61_ CLKNV 66_ FSVLL 71_ IFIYL 76_ LLMAV 81_ AVFLV 86_ YRTIT 91_ DFREK 96_ LKHPV 101_ MSVSY 106_ KEVDR 111_ YDAPG 116_ IALYP 121_ GQAQL 126_ LSCKH 131_ HYEVI 136_ PPLTS 141_ PGQPG 146_ DMNCT 151_ TQRIN 156_ YTDPF 161_ SNQTV 166_ KSALI 171_ VQGPR 176_ EVKKR 181_ ELVFL 186_ QFRLN 191_ KSSED 196_ FSAID 201_ YLLFS 206_ SFQEF 211_ LQSPN 216_ RVGFM 221_ QACES 226_ AYSSW 231_ KFSGG 236_ FRTWV 241_ KMSLV 246_ KTKEE 251_ DGREA 256_ VEFRQ 261_ ETSVV 266_ NYIDQ 271_ RPAAK 276_ KSAQL 281_ FFVVF 286_ EWKDP 291_ FIQKV 296_ QDIVT 301_ ANPWN 306_ TIALL 311_ CGAFL 316_ ALFKA 321_ AEFAK 326_ LSIKW 331_ MIKIR 336_ KRYLK 341_RRGQA
1: Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332)