Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein)
1_MALEV 6_ GDMED 11_ GQLSD 16_ SDSDM 21_ TVAPS 26_ DRPLQ 31_ LPKVL 36_ GGDSA 41_ MRAFQ 46_ NTATA 51_ CAPVS 56_ HYRAV 61_ ESVDS 66_ SEESF 71_ SDSDD 76_ DSCLW 81_ KRKRQ 86_ KCFNP 91_ PPKPE 96_ PFQFG 101_ QSSQK 106_ PPVAG 111_ GKKIN 116_ NIWGA 121_ VLQEQ 126_ NQDAV 131_ ATELG 136_ ILGME 141_ GTIDR 146_ SRQSE 151_ TYNYL 156_ LAKKL 161_ RKESQ 166_ EHTKD 171_ LDKEL 176_ DEYMH 181_ GGKKM 186_ GSKEE 191_ ENGQG 196_ HLKRK 201_ RPVKD 206_ RLGNR 211_ PEMNY 216_ KGRYE 221_ ITAED 226_ SQEKV 231_ ADEIS 236_ FRLQE 241_ PKKDL 246_ IARVV 251_ RIIGN 256_ KKAIE 261_ LLMET 266_ AEVEQ 271_ NGGLF 276_ IMNGS 281_ RRRTP 286_ GGVFL 291_ NLLKN 296_ TPSIS 301_ EEQIK 306_ DIFYI 311_ ENQKE 316_ YENKK 321_ AARKR 326_ RTQVL 331_ GKKMK 336_ QAIKS 341_ LNFQE 346_ DDDTS 351_ RETFA 356_ SDTNE 361_ ALASL 366_ DESQE 371_ GHAEA 376_ KLEAE 381_ EAIEV 386_DHSHD
1: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA