Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-)
1_MSGCG 6_ LFLRT 11_ TAAAR 16_ ACRGL 21_ VVSTA 26_ NRRLL 31_ RTSPP 36_ VRAFA 41_ KELFL 46_ GKIKK 51_ KEVFP 56_ FPEVS 61_ QDELN 66_ EINQF 71_ LGPVE 76_ KFFTE 81_ EVDSR 86_ KIDQE 91_ GKIPD 96_ ETLEK 101_ LKSLG 106_ LFGLQ 111_ VPEEY 116_ GGLGF 121_ SNTMY 126_ SRLGE 131_ IISMD 136_ GSITV 141_ TLAAH 146_ QAIGL 151_ KGIIL 156_ AGTEE 161_ QKAKY 166_ LPKLA 171_ SGEHI 176_ AAFCL 181_ TEPAS 186_ GSDAA 191_ SIRSR 196_ ATLSE 201_ DKKHY 206_ ILNGS 211_ KVWIT 216_ NGGLA 221_ NIFTV 226_ FAKTE 231_ VVDSD 236_ GSVKD 241_ KITAF 246_ IVERD 251_ FGGVT 256_ NGKPE 261_ DKLGI 266_ RGSNT 271_ CEVHF 276_ ENTKI 281_ PVENI 286_ LGEVG 291_ DGFKV 296_ AMNIL 301_ NSGRF 306_ SMGSV 311_ VAGLL 316_ KRLIE 321_ MTAEY 326_ ACTRK 331_ QFNKR 336_ LSEFG 341_ LIQEK 346_ FALMA 351_ QKAYV 356_ MESMT 361_ YLTAG 366_ MLDQP 371_ GFPDC 376_ SIEAA 381_ MVKVF 386_ SSEAA 391_ WQCVS 396_ EALQI 401_ LGGLG 406_ YTRDY 411_ PYERI 416_ LRDTR 421_ ILLIF 426_ EGTNE 431_ ILRMY 436_ IALTG 441_ LQHAG 446_ RILTT 451_ RIHEL 456_ KQAKV 461_ STVMD 466_ TVGRR 471_ LRDSL 476_ GRTVD 481_ LGLTG 486_ NHGVV 491_ HPSLA 496_ DSANK 501_ FEENT 506_ YCFGR 511_ TVETL 516_ LLRFG 521_ KTIME 526_ EQLVL 531_ KRVAN 536_ ILINL 541_ YGMTA 546_ VLSRA 551_ SRSIR 556_ IGLRN 561_ HDHEV 566_ LLANT 571_ FCVEA 576_ YLQNL 581_ FSLSQ 586_ LDKYA 591_ PENLD 596_ EQIKK 601_ VSQQI 606_ LEKRA 611_ YICAH 616_PLDRT
1: As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852)