E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)
1_MDQCV 6_ TVERE 11_ LEKVL 16_ HKFSG 21_ YGQLC 26_ ERGLE 31_ ELIDY 36_ TGGLK 41_ HEILQ 46_ SHGQD 51_ AELSG 56_ TLSLV 61_ LTQCC 66_ KRIKD 71_ TVQKL 76_ ASDHK 81_ DIHSS 86_ VSRVG 91_ KAIDK 96_ NFDSD 101_ ISSVG 106_ IDGCW 111_ QADSQ 116_ RLLNE 121_ VMVEH 126_ FFRQG 131_ MLDVA 136_ EELCQ 141_ ESGLS 146_ VDPSQ 151_ KEPFV 156_ ELNRI 161_ LEALK 166_ VRVLR 171_ PALEW 176_ AVSNR 181_ EMLIA 186_ QNSSL 191_ EFKLH 196_ RLYFI 201_ SLLMG 206_ GTTNQ 211_ REALQ 216_ YAKNF 221_ QPFAL 226_ NHQKD 231_ IQVLM 236_ GSLVY 241_ LRQGI 246_ ENSPY 251_ VHLLD 256_ ANQWA 261_ DICDI 266_ FTRDA 271_ CALLG 276_ LSVES 281_ PLSVS 286_ FSAGC 291_ VALPA 296_ LINIK 301_ AVIEQ 306_ RQCTG 311_ VWNQK 316_ DELPI 321_ EVDLG 326_ KKCWY 331_ HSIFA 336_ CPILR 341_ QQTTD 346_ NNPPM 351_ KLVCG 356_ HIISR 361_ DALNK 366_ MFNGS 371_ KLKCP 376_ YCPME 381_ QSPGD 386_AKQIF
1: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972)