Putative methyltransferase-like protein 7A (EC 2.1.1.-) (Protein AAM-B)
1_MELTI 6_ FILRL 11_ AIYIL 16_ TFPLY 21_ LLNFL 26_ GLWSW 31_ ICKKW 36_ FPYFL 41_ VRFTV 46_ IYNEQ 51_ MASKK 56_ RELFS 61_ NLQEF 66_ AGPSG 71_ KLSLL 76_ EVGCG 81_ TGANF 86_ KFYPP 91_ GCRVT 96_ CIDPN 101_ PNFEK 106_ FLIKS 111_ IAENR 116_ HLQFE 121_ RFVVA 126_ AGENM 131_ HQVAD 136_ GSVDV 141_ VVCTL 146_ VLCSV 151_ KNQER 156_ ILREV 161_ CRVLR 166_ PGGAF 171_ YFMEH 176_ VAAEC 181_ STWNY 186_ FWQQV 191_ LDPAW 196_ HLLFD 201_ GCNLT 206_ RESWK 211_ ALERA 216_ SFSKL 221_ KLQHI 226_ QAPLS 231_ WELVR 236_PHIYG
1: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358)
2: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation