Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3)
1_MAPWA 6_ EAEHS 11_ ALNPL 16_ RAVWL 21_ TLTAA 26_ FLLTL 31_ LLQLL 36_ PPGLL 41_ PGCAI 46_ FQDLI 51_ RYGKT 56_ KCGEP 61_ SRPAA 66_ CRAFD 71_ VPKRY 76_ FSHFY 81_ IISVL 86_ WNGFL 91_ LWCLT 96_ QSLFL 101_ GAPFP 106_ SWLHG 111_ LLRIL 116_ GAAQF 121_ QGGEL 126_ ALSAF 131_ LVLVF 136_ LWLHS 141_ LRRLF 146_ ECLYV 151_ SVFSN 156_ VMIHV 161_ VQYCF 166_ GLVYY 171_ VLVGL 176_ TVLSQ 181_ VPMDG 186_ RNAYI 191_ TGKNL 196_ LMQAR 201_ WFHIL 206_ GMMMF 211_ IWSSA 216_ HQYKC 221_ HVILG 226_ NLRKN 231_ KAGVV 236_ IHCNH 241_ RIPFG 246_ DWFEY 251_ VSSPN 256_ YLAEL 261_ MIYVS 266_ MAVTF 271_ GFHNL 276_ TWWLV 281_ VTNVF 286_ FNQAL 291_ SAFLS 296_ HQFYK 301_ SKFVS 306_ YPKHR 311_KAFLP
1: Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (PubMed:20637498, PubMed:38821050). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (PubMed:38821050). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:20637498, PubMed:38821050). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069)