MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B)
1_MSFLF 6_ SSRSS 11_ KTFKP 16_ KKNIP 21_ EGSHQ 26_ YELLK 31_ HAEAT 36_ LGSGN 41_ LRQAV 46_ MLPEG 51_ EDLNE 56_ WIAVN 61_ TVDFF 66_ NQINM 71_ LYGTI 76_ TEFCT 81_ EASCP 86_ VMSAG 91_ PRYEY 96_ HWADG 101_ TNIKK 106_ PIKCS 111_ APKYI 116_ DYLMT 121_ WVQDQ 126_ LDDET 131_ LFPSK 136_ IGVPF 141_ PKNFM 146_ SVAKT 151_ ILKRL 156_ FRVYA 161_ HIYHQ 166_ HFDSV 171_ MQLQE 176_ EAHLN 181_ TSFKH 186_ FIFFV 191_ QEFNL 196_ IDRRE 201_ LAPLQ 206_ ELIEK 211_LGSKD
1: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38