AKT-interacting protein (Ft1) (Fused toes protein homolog)
1_MNPFW 6_ SMSTS 11_ SVRKR 16_ SEGEE 21_ KTLTG 26_ DVKTS 31_ PPRTA 36_ PKKQL 41_ PSIPK 46_ NALPI 51_ TKPTS 56_ PAPAA 61_ QSTNG 66_ THASY 71_ GPFYL 76_ EYSLL 81_ AEFTL 86_ VVKQK 91_ LPGVY 96_ VQPSY 101_ RSALM 106_ WFGVI 111_ FIRHG 116_ LYQDG 121_ VFKFT 126_ VYIPD 131_ NYPDG 136_ DCPRL 141_ VFDIP 146_ VFHPL 151_ VDPTS 156_ GELDV 161_ KRAFA 166_ KWRRN 171_ HNHIW 176_ QVLMY 181_ ARRVF 186_ YKIDT 191_ ASPLN 196_ PEAAV 201_ LYEKD 206_ IQLFK 211_ SKVVD 216_ SVKVC 221_ TARLF 226_ DQPKI 231_ EDPYA 236_ ISFSP 241_ WNPSV 246_ HDEAR 251_ EKMLT 256_ QKKPE 261_ EQHNK 266_ SVHVA 271_ GLSWV 276_ KPGSV 281_ QPFSK 286_EEKTV
1: Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997)