Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
1_MAENS 6_ VLTST 11_ TGRTS 16_ LADSS 21_ IFDSK 26_ VTEIS 31_ KENLL 36_ IGSTS 41_ YVEEE 46_ MPQIE 51_ TRVIL 56_ VQEAG 61_ KQEEL 66_ IKALK 71_ TIKIM 76_ EVPVI 81_ KIKES 86_ CPGKS 91_ DEKLI 96_ KSVIN 101_ MDIKV 106_ GFVKM 111_ ESVEE 116_ FEGLD 121_ SPEFE 126_ NVFVV 131_ TDFQD 136_ SVFND 141_ LYKAD 146_ CRVIG 151_ PPVVL 156_ NCSQK 161_ GEPLP 166_ FSCRP 171_ LYCTS 176_ MMNLV 181_ LCFTG 186_ FRKKE 191_ ELVRL 196_ VTLVH 201_ HMGGV 206_ IRKDF 211_ NSKVT 216_ HLVAN 221_ CTQGE 226_ KFRVA 231_ VSLGT 236_ PIMKP 241_ EWIYK 246_ AWERR 251_ NEQDF 256_ YAAVD 261_ DFRNE 266_ FKVPP 271_ FQDCI 276_ LSFLG 281_ FSDEE 286_ KTNME 291_ EMTEM 296_ QGGKY 301_ LPLGD 306_ ERCTH 311_ LVVEE 316_ NIVKD 321_ LPFEP 326_ SKKLY 331_ VVKQE 336_ WFWGS 341_ IQMDA 346_ RAGET 351_ MYLYE 356_ KANTP 361_ ELKKS 366_ VSMLS 371_ LNTPN 376_ SNRKR 381_ RRLKE 386_ TLAQL 391_ SRETD 396_ VSPFP 401_ PRKRP 406_ SAEHS 411_ LSIGS 416_ LLDIS 421_ NTPES 426_ SINYG 431_ DTPKS 436_ CTKSS 441_ KSSTP 446_ VPSKQ 451_ SARWQ 456_ VAKEL 461_ YQTES 466_ NYVNI 471_ LATII 476_ QLFQV 481_ PLEEE 486_ GQRGG 491_ PILAP 496_ EEIKT 501_ IFGSI 506_ PDIFD 511_ VHTKI 516_ KDDLE 521_ DLIVN 526_ WDESK 531_ SIGDI 536_ FLKYS 541_ KDLVK 546_ TYPPF 551_ VNFFE 556_ MSKET 561_ IIKCE 566_ KQKPR 571_ FHAFL 576_ KINQA 581_ KPECG 586_ RQSLV 591_ ELLIR 596_ PVQRL 601_ PSVAL 606_ LLNDL 611_ KKHTA 616_ DENPD 621_ KSTLE 626_ KAIGS 631_ LKEVM 636_ THINE 641_ DKRKT 646_ EAQKQ 651_ IFDVV 656_ YEVDG 661_ CPANL 666_ LSSHR 671_ SLVQR 676_ VETIS 681_ LGEHP 686_ CDRGE 691_ QVTLF 696_ LFNDC 701_ LEIAR 706_ KRHKV 711_ IGTFR 716_ SPHGQ 721_ TRPPA 726_ SLKHI 731_ HLMPL 736_ SQIKK 741_ VLDIR 746_ ETEDC 751_ HNAFA 756_ LLVRP 761_ PTEQA 766_ NVLLS 771_ FQMTS 776_ DELPK 781_ ENWLK 786_ MLCRH 791_ VANTI 796_ CKADA 801_ ENLIY 806_ TADPE 811_ SFEVN 816_ TKDMD 821_ STLSR 826_ ASRAI 831_ KKTSK 836_ KVTRA 841_ FSFSK 846_ TPKRA 851_ LRRAL 856_ MTSHG 861_ SVEGR 866_ SPSSN 871_ DKHVM 876_ SRLSS 881_ TSSLA 886_ GIPSP 891_ SLVSL 896_ PSFFE 901_ RRSHT 906_LSRST
1: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death