Tripartite motif-containing protein 45 (RING finger protein 99)
1_MSENR 6_ KPLLG 11_ FVSKL 16_ TSGTA 21_ LGNSG 26_ KTHCP 31_ LCLGL 36_ FKAPR 41_ LLPCL 46_ HTVCT 51_ TCLEQ 56_ LEPFS 61_ VVDIR 66_ GGDSD 71_ TSSEG 76_ SIFQE 81_ LKPRS 86_ LQSQI 91_ GILCP 96_ VCDAQ 101_ VDLPM 106_ GGVKA 111_ LTIDH 116_ LAVND 121_ VMLES 126_ LRGEG 131_ QGLVC 136_ DLCND 141_ REVEK 146_ RCQTC 151_ KANLC 156_ HFCCQ 161_ AHRRQ 166_ KKTTY 171_ HTMVD 176_ LKDLK 181_ GYSRI 186_ GKPIL 191_ CPVHP 196_ AEELR 201_ LFCEF 206_ CDRPV 211_ CQDCV 216_ VGEHR 221_ EHPCD 226_ FTSNV 231_ IHKHG 236_ DSVWE 241_ LLKGT 246_ QPHVE 251_ ALEEA 256_ LAQIH 261_ IINSA 266_ LQKRV 271_ EAVAA 276_ DVRTF 281_ SEGYI 286_ KAIEE 291_ HRDKL 296_ LKQLE 301_ DIRAQ 306_ KENSL 311_ QLQKA 316_ QLEQL 321_ LADMR 326_ TGVEF 331_ TEHLL 336_ TSGSD 341_ LEILI 346_ TKRVV 351_ VERLR 356_ KLNKV 361_ QYSTR 366_ PGVND 371_ KIRFC 376_ PQEKA 381_ GQCRG 386_ YEIYG 391_ TINTK 396_ EVDPA 401_ KCVLQ 406_ GEDLH 411_ RAREK 416_ QTASF 421_ TLLCK 426_ DAAGE 431_ IMGRG 436_ GDNVQ 441_ VAVVP 446_ KDKKD 451_ SPVRT 456_ MVQDN 461_ KDGTY 466_ YISYT 471_ PKEPG 476_ VYTVW 481_ VCIKE 486_ QHVQG 491_ SPFTV 496_ MVRRK 501_ HRPHS 506_ GVFHC 511_ CTFCS 516_ SGGQK 521_ TARCA 526_ CGGTM 531_ PGGYL 536_ GCGHG 541_ HKGHP 546_ GHPHW 551_ SCCGK 556_ FNEKS 561_ ECTWT 566_ GGQSA 571_PRSLL
1: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway