Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)
1_MEEGK 6_ MDENE 11_ WGYHG 16_ EGNKS 21_ LVVAH 26_ AQRCV 31_ VLRFL 36_ KFPPN 41_ RKKTS 46_ EEIFQ 51_ HLQNI 56_ VDFGK 61_ NVMKE 66_ FLGEN 71_ YVHYG 76_ EVVQL 81_ PLEFV 86_ KQLCL 91_ KIQSE 96_ RPESR 101_ CDKDL 106_ DTLSG 111_ YAMCL 116_ PNLTR 121_ LQTYR 126_ FAEHR 131_ PILCV 136_ EIKPK 141_ CGFIP 146_ FSSDV 151_ THEMK 156_ HKVCR 161_ YCMHQ 166_ HLKVA 171_ TGKWK 176_ QISKY 181_ CPLDL 186_ YSGNK 191_ QRMHF 196_ ALKSL 201_ LQEAQ 206_ NNLKI 211_ FKNGE 216_ LIYGC 221_ KDARS 226_ PVADW 231_ SELAH 236_ HLKPF 241_ FFPSN 246_ GLASG 251_ PHCTR 256_ AVIRE 261_ LVHVI 266_ TRVLL 271_ SGSDK 276_ GRAGT 281_ LSPGL 286_ GPQGP 291_ RVCEA 296_ SPFSR 301_ SLRCQ 306_ GKNTP 311_ ERSGL 316_ PKGCL 321_ LYKTL 326_ QVQML 331_ DLLDI 336_ EGLYP 341_ LYNRV 346_ ERYLE 351_ EFPEE 356_ RKTLQ 361_ IDGPY 366_ DEAFY 371_ QKLLD 376_ LSTED 381_ DGTVA 386_ FALTK 391_ VQQYR 396_ VAMTA 401_ KDCSI 406_ MIALS 411_ PCLQD 416_ ASSDQ 421_ RPVVP 426_ SSRSR 431_ FAFSV 436_ SVLDL 441_ DLKPY 446_ ESIPH 451_ QYKLD 456_ GKIVN 461_ YYSKT 466_ VRAKD 471_ NAVMS 476_ TRFKE 481_ SEDCT 486_LVLHK
1: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis