Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399)
1_MDTRS 6_ GSQCS 11_ VTPEA 16_ ILNNE 21_ KLVLP 26_ PRISR 31_ VNGWS 36_ LPLHY 41_ FQVVT 46_ WAVFV 51_ GLSSA 56_ TFGIF 61_ IPFLP 66_ HAWKY 71_ IAYVV 76_ TGGIF 81_ SFHLV 86_ VHLIA 91_ SCIDP 96_ ADSNV 101_ RLMKN 106_ YSQPM 111_ PLFDR 116_ SKHAH 121_ VIQNQ 126_ FCHLC 131_ KVTVN 136_ KKTKH 141_ CISCN 146_ KCVSG 151_ FDHHC 156_ KWINN 161_ CVGSR 166_ NYWFF 171_ FSTVA 176_ SATAG 181_ MLCLI 186_ AILLY 191_ VLVQY 196_ LVNPG 201_ VLRTD 206_ PRYED 211_ VKNMN 216_ TWLLF 221_ LPLFP 226_ VQVQT 231_ LIVVI 236_ IGMLV 241_ LLLDF 246_ LGLVH 251_ LGQLL 256_ IFHIY 261_ LKAKK 266_ MTTFE 271_ YLINN 276_ RKEES 281_ SKHQA 286_ VRKDP 291_ YVQMD 296_ KGVLQ 301_ QGAGA 306_ LGSSA 311_ QGVKA 316_ KSSLL 321_ IHKHL 326_ CHFCT 331_ SVNQD 336_ GDSTA 341_ REGDE 346_ DPCPS 351_ ALGAK 356_ ARNSR 361_ LICRR 366_ LCQFS 371_ TRVHP 376_ DGGSM 381_ AQEAD 386_ DAPSI 391_ STLGL 396_ QQETT 401_ EPMKT 406_DSAES
1: Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). May play a role in cell proliferation (PubMed:28331227)
2: Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:28331227). Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:28331227)