Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744)
1_MSPAP 6_ DAAPA 11_ PASIS 16_ LFDLS 21_ ADAPV 26_ FQGLS 31_ LVSHA 36_ PGEAL 41_ ARAPR 46_ TSCSG 51_ SGERE 56_ SPERK 61_ LLQGP 66_ MDISE 71_ KLFCS 76_ TCDQT 81_ FQNHQ 86_ EQREH 91_ YKLDW 96_ HRFNL 101_ KQRLK 106_ DKPLL 111_ SALDF 116_ EKQSS 121_ TGDLS 126_ SISGS 131_ EDSDS 136_ ASEED 141_ LQTLD 146_ RERAT 151_ FEKLS 156_ RPPGF 161_ YPHRV 166_ LFQNA 171_ QGQFL 176_ YAYRC 181_ VLGPH 186_ QDPPE 191_ EAELL 196_ LQNLQ 201_ SRGPR 206_ DCVVL 211_ MAAAG 216_ HFAGA 221_ IFQGR 226_ EVVTH 231_ KTFHR 236_ YTVRA 241_ KRGTA 246_ QGLRD 251_ ARGGP 256_ SHSAG 261_ ANLRR 266_ YNEAT 271_ LYKDV 276_ RDLLA 281_ GPSWA 286_ KALEE 291_ AGTIL 296_ LRAPR 301_ SGRSL 306_ FFGGK 311_ GAPLQ 316_ RGDPR 321_ LWDIP 326_ LATRR 331_ PTFQE 336_ LQRVL 341_ HKLTT 346_ LHVYE 351_ EDPRE 356_ AVRLH 361_ SPQTH 366_ WKTVR 371_ EERKK 376_ PTEEE 381_ IRKIC 386_ RDEKE 391_ ALGQN 396_ EESPK 401_ QGSGS 406_ EGEDG 411_ FQVEL 416_ ELVEL 421_ TVGTL 426_ DLCES 431_ EVLPK 436_ RRRRK 441_ RNKKE 446_ KSRDQ 451_ EAGAH 456_ RTLLQ 461_ QTQEE 466_ EPSTQ 471_ SSQAV 476_ AAPLG 481_ PLLDE 486_ AKAPG 491_ QPELW 496_ NALLA 501_ ACRAG 506_ DVGVL 511_ KLQLA 516_ PSPAD 521_ PRVLS 526_ LLSAP 531_ LGSGG 536_ FTLLH 541_ AAAAA 546_ GRGSV 551_ VRLLL 556_ EAGAD 561_ PTVQD 566_ SRARP 571_ PYTVA 576_ ADKST 581_ RNEFR 586_ RFMEK 591_ NPDAY 596_ DYNKA 601_ QVPGP 606_ LTPEM 611_ EARQA 616_ TRKRE 621_ QKAAR 626_ RQREE 631_ QQQRQ 636_ QEQEE 641_ REREE 646_ QRRFA 651_ ALSDR 656_ EKRAL 661_ AAERR 666_ LAAQL 671_ GAPTS 676_ PIPDS 681_ AIVNT 686_ RRCWS 691_ CGASL 696_ QGLTP 701_ FHYLD 706_ FSFCS 711_ TRCLQ 716_ DHRRQ 721_AGRPS
1: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725)