Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)
1_MGSSQ 6_ SVEIP 11_ GGGTE 16_ GYHVL 21_ RVQEN 26_ SPGHR 31_ AGLEP 36_ FFDFI 41_ VSING 46_ SRLNK 51_ DNDTL 56_ KDLLK 61_ ANVEK 66_ PVKML 71_ IYSSK 76_ TLELR 81_ ETSVT 86_ PSNLW 91_ GGQGL 96_ LGVSI 101_ RFCSF 106_ DGANE 111_ NVWHV 116_ LEVES 121_ NSPAA 126_ LAGLR 131_ PHSDY 136_ IIGAD 141_ TVMNE 146_ SEDLF 151_ SLIET 156_ HEAKP 161_ LKLYV 166_ YNTDT 171_ DNCRE 176_ VIITP 181_ NSAWG 186_ GEGSL 191_ GCGIG 196_ YGYLH 201_ RIPTR 206_ PFEEG 211_ KKISL 216_ PGQMA 221_ GTPIT 226_ PLKDG 231_ FTEVQ 236_ LSSVN 241_ PPSLS 246_ PPGTT 251_ GIEQS 256_ LTGLS 261_ ISSTP 266_ PAVSS 271_ VLSTG 276_ VPTVP 281_ LLPPQ 286_ VNQSL 291_ TSVPP 296_ MNPAT 301_ TLPGL 306_ MPLPA 311_ GLPNL 316_ PNLNL 321_ NLPAP 326_ HIMPG 331_ VGLPE 336_ LVNPG 341_ LPPLP 346_ SMPPR 351_ NLPGI 356_ APLPL 361_ PSEFL 366_ PSFPL 371_ VPESS 376_ SAASS 381_ GELLS 386_ SLPPT 391_ SNAPS 396_ DPATT 401_ TAKAD 406_ AASSL 411_ TVDVT 416_ PPTAK 421_ APTTV 426_ EDRVG 431_ DSTPV 436_ SEKPV 441_ SAAVD 446_ANASE
1: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262)