Protein zwilch homolog (hZwilch)
1_MWERL 6_ NCAAE 11_ DFYSR 16_ LLQKF 21_ NEEKK 26_ GIRKD 31_ PFLYE 36_ ADVQV 41_ QLISK 46_ GQPNP 51_ LKNIL 56_ NENDI 61_ VFIVE 66_ KVPLE 71_ KEETS 76_ HIEEL 81_ QSEET 86_ AISDF 91_ STGEN 96_ VGPLA 101_ LPVGK 106_ ARQLI 111_ GLYTM 116_ AHNPN 121_ MTHLK 126_ INLPV 131_ TALPP 136_ LWVRC 141_ DSSDP 146_ EGTCW 151_ LGAEL 156_ ITTNN 161_ SITGI 166_ VLYVV 171_ SCKAD 176_ KNYSV 181_ NLENL 186_ KNLHK 191_ KRHHL 196_ STVTS 201_ KGFAQ 206_ YELFK 211_ SSALD 216_ DTITA 221_ SQTAI 226_ ALDIS 231_ WSPVD 236_ EILQI 241_ PPLSS 246_ TATLN 251_ IKVES 256_ GEPRG 261_ PLNHL 266_ YRELK 271_ FLLVL 276_ ADGLR 281_ TGVTE 286_ WLEPL 291_ EAKSA 296_ VELVQ 301_ EFLND 306_ LNKLD 311_ GFGDS 316_ TKKDT 321_ EVETL 326_ KHDTA 331_ AVDRS 336_ VKRLF 341_ KVRSD 346_ LDFAE 351_ QLWCK 356_ MSSSV 361_ ISYQD 366_ LVKCF 371_ TLIIQ 376_ SLQRG 381_ DIQPW 386_ LHSGS 391_ NSLLS 396_ KLIHQ 401_ SYHGT 406_ MDTVS 411_ LSGTI 416_ PVQML 421_ LEIGL 426_ DKLKK 431_ DYISF 436_ FIGQE 441_ LASLN 446_ HLEYF 451_ IAPSV 456_ DIQEQ 461_ VYRVQ 466_ KLHHI 471_ LEILV 476_ SCMPF 481_ IKSQH 486_ ELLFS 491_ LTQIC 496_ IKYYK 501_ QNPLD 506_ EQHIF 511_ QLPVR 516_ PTAVK 521_ NLYQS 526_ EKPQK 531_ WRVEI 536_ YSGQK 541_ KIKTV 546_ WQLSD 551_ SSPID 556_ HLNFH 561_ KPDFS 566_ ELTLN 571_ GSLEE 576_ RIFFT 581_ NMVTC 586_SQVHF
1: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131)