Gene name: RNF121

Uniprot entry:

Q9H920

Protein names:

RING finger protein 121

Protein sequence:

1_MAAVV 6_ EVEVG 11_ GGAAG 16_ ERELD 21_ EVDMS 26_ DLSPE 31_ EQWRV 36_ EHARM 41_ HAKHR 46_ GHEAM 51_ HAEMV 56_ LILIA 61_ TLVVA 66_ QLLLV 71_ QWKQR 76_ HPRSY 81_ NMVTL 86_ FQMWV 91_ VPLYF 96_ TVKLH 101_ WWRFL 106_ VIWIL 111_ FSAVT 116_ AFVTF 121_ RATRK 126_ PLVQT 131_ TPRLV 136_ YKWFL 141_ LIYKI 146_ SYATG 151_ IVGYM 156_ AVMFT 161_ LFGLN 166_ LLFKI 171_ KPEDA 176_ MDFGI 181_ SLLFY 186_ GLYYG 191_ VLERD 196_ FAEMC 201_ ADYMA 206_ STIGF 211_ YSESG 216_ MPTKH 221_ LSDSV 226_ CAVCG 231_ QQIFV 236_ DVSEE 241_ GIIEN 246_ TYRLS 251_ CNHVF 256_ HEFCI 261_ RGWCI 266_ VGKKQ 271_ TCPYC 276_ KEKVD 281_ LKRMF 286_ SNPWE 291_ RPHVM 296_ YGQLL 301_ DWLRY 306_ LVAWQ 311_ PVIIG 316_ VVQGI 321_NYILG

Protein annotations

Protein functions:

1: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity)