Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (hTRFP)
1_MGVTC 6_ VSQMP 11_ VAEGK 16_ SVQQT 21_ VELLT 26_ RKLEM 31_ LGAEK 36_ QGTFC 41_ VDCET 46_ YHTAA 51_ STLGS 56_ QGQTG 61_ KLMYV 66_ MHNSE 71_ YPLSC 76_ FALFE 81_ NGPCL 86_ IADTN 91_ FDVLM 96_ VKLKG 101_ FFQSA 106_ KASKI 111_ ETRGT 116_ RYQYC 121_ DFLVK 126_ VGTVT 131_ MGPSA 136_ RGISV 141_ EVEYG 146_ PCVVA 151_ SDCWS 156_ LLLEF 161_ LQSFL 166_ GSHTP 171_ GAPAV 176_ FGNRH 181_ DAVYG 186_ PADTM 191_ VQYME 196_ LFNKI 201_ RKQQQ 206_VPVAG
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors